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Titolo:
AMIODARONE INDUCES A DIFFERENT PATTERN OF ULTRASTRUCTURAL CHANGE IN THE THYROID TO IODINE EXCESS ALONE IN BOTH THE BB W RAT AND THE WISTAR RAT/
Autore:
PITSIAVAS V; SMERDELY P; LI M; BOYAGES SC;
Indirizzi:
WESTMEAD HOSP,ICPMR,LAB ENDOCRINOL WESTMEAD NSW 2145 AUSTRALIA WESTMEAD HOSP,DEPT DIABET WESTMEAD NSW 2145 AUSTRALIA WESTMEAD HOSP,DEPT ENDOCRINOL WESTMEAD NSW 2145 AUSTRALIA
Titolo Testata:
European journal of endocrinology
fascicolo: 1, volume: 137, anno: 1997,
pagine: 89 - 98
SICI:
0804-4643(1997)137:1<89:AIADPO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LYMPHOCYTIC THYROIDITIS; PULMONARY TOXICITY; INDUCED THYROTOXICOSIS; INCLUSION-BODIES; DESETHYLAMIODARONE; HEPATOCYTES; LIVER; LUNG; INTERLEUKIN-6; THYROGLOBULIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
V. Pitsiavas et al., "AMIODARONE INDUCES A DIFFERENT PATTERN OF ULTRASTRUCTURAL CHANGE IN THE THYROID TO IODINE EXCESS ALONE IN BOTH THE BB W RAT AND THE WISTAR RAT/", European journal of endocrinology, 137(1), 1997, pp. 89-98

Abstract

Amiodarone (AMD)-induced toxicity can be a life-threatening complication which limits the use of amiodarone as an anti-arrhythmic agent. The aim of the present study was to determine the nature of AMD toxicityby comparing ultrastructural changes induced by AMD and equivalent amounts of iodide in two animal models, the Wistar and the autoimmune BB/W rat. Rats were divided into control (water), AMD- (30 mg AMD/kg) oriodide-treated (10 mg/kg) groups. Thyroids were removed at 15 weeks and processed for electron microscopy. We found that AMD induced specific ultrastructural changes of thyroid cytotoxicity in both rat models,which were distinct compared with changes induced by excess iodide alone. Specific changes included marked distortion of thyroid architecture, evidence of necrosis and apoptosis, inclusion bodies, lipofuscinogenesis and markedly dilated endoplasmic reticulum (ER). Our data indicate that AMD is directly cytotoxic to the thyroid an effect mediated by disruption of subcellular organelle function. ER dilatation is suggestive that AMD cytotoxicity may be mediated through disruption of the protein sorting pathways leading to a drug-induced form of ER storage disease. The predilection of the thyroid to AMD may be explained by the additive effects of excess iodine and AMD drug toxicity on protein sorting pathways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 09:43:06