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Titolo:
Time-dependent influence of pentoxifylline on the pharmacokinetics of orally administered carbamazepine in human subjects
Autore:
Poondru, S; Devaraj, R; Boinpally, RR; Yamsani, MR;
Indirizzi:
Kakatiya Univ, Coll Pharmaceut Sci, Warangal 506009, Andhra Pradesh, IndiaKakatiya Univ Warangal Andhra Pradesh India 506009 Andhra Pradesh, India
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 3, volume: 43, anno: 2001,
pagine: 301 - 305
SICI:
1043-6618(200103)43:3<301:TIOPOT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINICAL PHARMACOKINETICS; CHRONOPHARMACOKINETICS; NEUROTOXICITY; DIAZEPAM;
Keywords:
carbamazepine; pentoxifylline; pharmacokinetic-interaction; time-dependent interaction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Devaraj, R Kakatiya Univ, Coll Pharmaceut Sci, Warangal 506009, Andhra Pradesh, India Kakatiya Univ Warangal Andhra Pradesh India 506009 desh, India
Citazione:
S. Poondru et al., "Time-dependent influence of pentoxifylline on the pharmacokinetics of orally administered carbamazepine in human subjects", PHARMAC RES, 43(3), 2001, pp. 301-305

Abstract

The time-dependent influence of pentoxifylline (PTX) on the pharmacokinetics of carbamazepine (CBZ) was studied after single-dose oral administrationof 100 mg CBZ either alone or in combination with 400 mg PTX at 10:00 and 22:00 h. Serum samples were collected at predetermined time intervals and analysed for unchanged CBZ using high-performance liquid chromatography. Thepharmacokinetic parameters of CBZ were calculated using the model-independent method. PTX reduced the rate (T-max, 8.58 +/- 2.64 vs 5.66 +/- 1.44 h, K-a; 0.47 +/- 0.14 vs 0.72 +/- 0.19 h(-1)), but not the extent of CBZ absorption at 22:00 h treatment. However, such a change was not observed for 10:00 h treatment. No significant changes were observed in other pharmacokinetic parameters of CBZ under the influence of PTX for both 10:00 h as well as22:00 h treatments. The clinical significance of the time-dependent influence of PTX on the rate of absorption of CBZ will be revealed upon extensionof the study to patients. (C) 2001 Academic Press.

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Documento generato il 02/04/20 alle ore 00:14:59