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Titolo:
Effects of intrastriatal infusion of D2 and D3 dopamine receptor preferring antagonists on dopamine release in rat dorsal striatum (in vivo microdialysis study)
Autore:
Sotnikova, TD; Gainetdinov, RR; Grekhova, TV; Rayevsky, KS;
Indirizzi:
Russian Acad Med Sci, Inst Pharmacol, Lab Neurochem Pharmacol, Moscow 125315, Russia Russian Acad Med Sci Moscow Russia 125315 armacol, Moscow 125315, Russia
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 3, volume: 43, anno: 2001,
pagine: 283 - 290
SICI:
1043-6618(200103)43:3<283:EOIIOD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE-HYDROXYLASE ACTIVITY; FREELY MOVING RATS; BRAIN DIALYSIS; D-3 RECEPTOR; CONSCIOUS RATS; IN-VIVO; METABOLISM; AGONISTS; MECHANISM; DRUGS;
Keywords:
D2 and D3 dopamine receptor preferring antagonists; neuroleptics; 7-OH-DPAT; D2 dopamine receptor; D3 dopamine receptor; dopamine release; microdialysis; rat dorsal striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Gainetdinov, RR Duke Univ, Med Ctr, Box 3287,DUMC, Durham, NC 27710 USA Duke Univ Box 3287,DUMC Durham NC USA 27710 , NC 27710 USA
Citazione:
T.D. Sotnikova et al., "Effects of intrastriatal infusion of D2 and D3 dopamine receptor preferring antagonists on dopamine release in rat dorsal striatum (in vivo microdialysis study)", PHARMAC RES, 43(3), 2001, pp. 283-290

Abstract

Dopamine D2-1ike receptor antagonists haloperidol, spiperone, clozapine, cis-(+)-(1s,2R)-5-methoxy-1-methyl-2-(n-propylamino)tetralin, (+)-AJ76, cis-(+)-(1s,2R)-5-methoxy-1-methyl-2-(n-di-propylamino)tetralin, (+)-UH232, andputative D3 dopamine receptor agonist (+/-)-7-hydroxy-N,N-di-n-propyl-2-aminotetralin, 7-OH-DPAT, were infused via a transcerebral microdialysis probe into the dorsal striatum of freely moving rats. Local infusion of all thedopamine antagonists studied resulted in concentration-dependent increase of striatal dopamine release in vivo. Subsequent i.p. administration of thedrugs did not produce a further rise of dopamine release as compared to the maximal increase elicited by local administration of the same substances. The difference between effects of D2 and D3 dopamine receptor preferring antagonists applied locally was observed only in the degree of dopamine release elevation [the maximal responses were about 160% for haloperidol and spiperone, 190% for clozapine and (+)-UH232 and 400% for (+)-AJ76, of basal]. Striatal 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) levels were elevated only slightly following local infusion of haloperidol, spiperone and clozapine, while systemic administration of the drugs resulted in a marked increase of metabolite extracellular levels. Both (+)-UH232 and (+)-AJ76 were found to increase significantly DOPAC and HVA levels during infusion, but the effect was less pronounced in comparison to that produced by systemic drug administration. Infusion of 7-OH-DPAT in the concentration range 5 x 10(-9) to 10(-6) M significantly decreased dopamine release but not metabolite levels down to the values observed following systemic drug administration. The present results give further evidence for the hypothesized leading role of nerve terminal dopamine autoreceptors, presumably of D3 type, in neuroleptic-induced augmentation of dopamine release in rat dorsal striatum. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:09:01