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Titolo:
Gastric motor effects of triptans: Open questions and future perspectives
Autore:
Cipolla, G; Sacco, S; Crema, F; Moro, E; De Ponti, F; Frigo, G;
Indirizzi:
Univ Pavia, Dept Internal Med & Therapeut, I-27100 Pavia, Italy Univ Pavia Pavia Italy I-27100 nal Med & Therapeut, I-27100 Pavia, Italy Univ Bologna, Dept Pharmacol, Bologna, Italy Univ Bologna Bologna ItalyUniv Bologna, Dept Pharmacol, Bologna, Italy
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 3, volume: 43, anno: 2001,
pagine: 205 - 210
SICI:
1043-6618(200103)43:3<205:GMEOTO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISOLATED CORONARY-ARTERY; DOUBLE-BLIND; GASTROESOPHAGEAL REFLUX; FUNCTIONAL DYSPEPSIA; AGONIST SUMATRIPTAN; RIZATRIPTAN MK-462; 5-HT1D RECEPTORS; HEALTHY-SUBJECTS; 5HT(1) AGONIST; ACUTE MIGRAINE;
Keywords:
triptans; antimigraine agents; gastrointestinal motility; dyspepsia; 5-HT receptors;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Frigo, G Univ Pavia, Dept Internal Med & Therapeut, Piazza Botta 10, I-27100 Pavia,Italy Univ Pavia Piazza Botta 10 Pavia Italy I-27100 27100 Pavia,Italy
Citazione:
G. Cipolla et al., "Gastric motor effects of triptans: Open questions and future perspectives", PHARMAC RES, 43(3), 2001, pp. 205-210

Abstract

Sumatriptan is a 5-HT1B/D receptor agonist of documented efficacy in relieving migraine and associated symptoms such as nausea and vomiting. In the past decade, several studies reported an important delay of gastric emptyinginduced by sumatriptan in healthy humans. The impact of this gastric motoreffect of sumatriptan in migraineurs is difficult to predict: a further delay in gastric emptying could be detrimental (i.e. increased nausea and epigastric symptoms) in patients already having delayed gastric emptying. However, in patients with functional dyspepsia, sumatriptan is also reported toimprove gastric accommodation to a meal and reduce perception of gastric distention, hence relieving epigastric symptoms. Thus, reduced visceral perception could be a mechanism involved in reducing nausea during a migraine attack. Paradoxically, sumatriptan is reported both to relieve the nausea ofa migraine attack and to have nausea as a side effect. Although careful analysis of the time of onset of nausea may offer a clue as to the origin of this symptom, available data do not support definite conclusions, all the more so because the gastric motor effect of second-generation triptans are still unexplored. Taken together, the available evidence warrants further studies to clarify the following issues: first, the mechanism responsible forthe gastric motor effect of sumatriptan [receptor subtype(s) involved; central vs peripheral mechanism]; secondly, the effects on gastric motility/visceral sensitivity of second-generation triptans (which are 5-HT1B/D receptor agonists) and more recent selective 5-HT1D receptor agonists (proposed as investigational antimigraine agents with less potential to induce coronary vasoconstriction through 5-HT1B receptors); finally, the possible use of drugs improving gastric accommodation to a meal in the management of those dyspeptic patients with impaired fundic relaxation/altered visceral sensitivity. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:01:29