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Titolo:
Plasma levels of amino acids and hypermetabolism in patients with chronic obstructive pulmonary disease
Autore:
Yoneda, T; Yoshikawa, M; Fu, A; Tsukaguchi, K; Okamoto, Y; Takenaka, H;
Indirizzi:
Nara Med Univ, Dept Internal Med 2, Kashihara, Nara 6348522, Japan Nara Med Univ Kashihara Nara Japan 6348522 Kashihara, Nara 6348522, Japan
Titolo Testata:
NUTRITION
fascicolo: 2, volume: 17, anno: 2001,
pagine: 95 - 99
SICI:
0899-9007(200102)17:2<95:PLOAAA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALNOURISHED PATIENTS; NUTRITION; EMPHYSEMA; MUSCLE;
Keywords:
nutritional assessment; chronic obstructive pulmonary disease; branched-chain amino acid; resting energy expenditure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Yoneda, T Nara Med Univ, Dept Internal Med 2, 840 Shijo Cho, Kashihara, Nara 6348522, Japan Nara Med Univ 840 Shijo Cho Kashihara Nara Japan 6348522 , Japan
Citazione:
T. Yoneda et al., "Plasma levels of amino acids and hypermetabolism in patients with chronic obstructive pulmonary disease", NUTRITION, 17(2), 2001, pp. 95-99

Abstract

Plasma levels of amino acids were measured by ion-exchange, high-pressure liquid chromatography in 30 ambulatory patients with chronic obstructive pulmonary disease (COPD; mean +/- SD: age 64 +/- 13 y and forced expiratory volume in 1 s [FEV1] 0.85 +/- 0.25 L) and 30 age- and sex-matched healthy control subjects with regard to nutritional status, resting energy expenditure (REE), and pulmonary function. The ratio of branched-chain amino acids toaromatic amino acids was significantly (P < 0.001) decreased in COPD patients and was significantly correlated with percentage of ideal body weight (r = 0.403, P < 0.05, percentage of arm-muscle circumference (r = 0.492, P <0.01), and %FEV1 (r = 0.467, P < 0.05). Plasma levels of alanine and cysteine were decreased, whereas levels of glutamine, aspartic acid, serine, andornithine were elevated in COPD patients as opposed to control subjects. The ratio of resting energy expenditure to predicted resting energy expenditure was negatively correlated with the ratio of branched-chain to aromatic amino acids (r = -0.716, P < 0.01), percentage of arm-muscle-circumference (r = -0.770, P < 0.05), %FEV1 (r = -0.839, P < 0.01), and the maximal inspiratory pressure (r = -0.803, P < 0.001). Underweight CORD patients also exhibited a greater degree of hyperinflation (percentage of residual volume = 205 +/- 15 for underweight patients and 156 +/- 8 for normal-weight patients). In conclusion, a decrease in plasma levels of branched-chain amino acids in relation to hypermetabolism, possibly resulting from the severity of COPD and respiratory muscle weakness, and various disturbances in plasma amino-acid levels were found in underweight COPD patients. (C) Elsevier Science Inc. 2001.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 00:59:46