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Titolo:
New 3 '-deoxythymidines bearing a nucleophilic 3 '-substituent
Autore:
Belostotskii, AM; Keren-Yeshuah, H; Lexner, J; Hassner, A;
Indirizzi:
Bar Ilan Univ, Dept Chem, IL-52900 Ramat Gan, Israel Bar Ilan Univ Ramat Gan Israel IL-52900 Chem, IL-52900 Ramat Gan, Israel
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 1-2, volume: 20, anno: 2001,
pagine: 93 - 101
SICI:
1525-7770(2001)20:1-2<93:N3'BAN>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIV REVERSE-TRANSCRIPTASE; ANALOGS; SUGARS; AZT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Belostotskii, AM Bar Ilan Univ, Dept Chem, IL-52900 Ramat Gan, Israel Bar Ilan Univ Ramat Gan Israel IL-52900 mat Gan, Israel
Citazione:
A.M. Belostotskii et al., "New 3 '-deoxythymidines bearing a nucleophilic 3 '-substituent", NUCLEOS NUC, 20(1-2), 2001, pp. 93-101

Abstract

New potential cancer-driven as well as HIV-driven nucleoside heteroanalogs, such as 3'-thio- and 3'- as well as 5'-selenosubstituted thymidines, havebeen synthesized. We also report an effective method for the preparation of novel nucleoside derivatives, bis(deoxynucleoside) diselenides, in nearlyquantitative yields. The North conformation is significantly populated in the conformational equilibrium for-3'-alpha -alkylthiothymidines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:16:59