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Titolo:
Preparation of oligodeoxynucleotides containing 5-(N-methylpiperazinyl) and 5-benzyloxymethyl uracils
Autore:
Megied, AESA; Ali, OM; Kofoed, T; Pedersen, EB;
Indirizzi:
Menoufia Univ, Fac Sci, Dept Chem, Shebien El Koam, Egypt Menoufia Univ Shebien El Koam Egypt , Dept Chem, Shebien El Koam, Egypt Odense Univ, Dept Chem, DK-5230 Odense M, Denmark Odense Univ Odense Denmark M Univ, Dept Chem, DK-5230 Odense M, Denmark
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 1-2, volume: 20, anno: 2001,
pagine: 1 - 9
SICI:
1525-7770(2001)20:1-2<1:POOC5A>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTISENSE OLIGONUCLEOTIDES; NUCLEOSIDES; ANALOGS; ROUTE;
Keywords:
nucleosides; 5 '-O-DMT nucleosides; nucleoside-3 '-phosphoramidites; oligodeoxynucleotide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Megied, AESA Menoufia Univ, Fac Sci, Dept Chem, Shebien El Koam, Egypt Menoufia Univ Shebien El Koam Egypt Shebien El Koam, Egypt
Citazione:
A.E.S.A. Megied et al., "Preparation of oligodeoxynucleotides containing 5-(N-methylpiperazinyl) and 5-benzyloxymethyl uracils", NUCLEOS NUC, 20(1-2), 2001, pp. 1-9

Abstract

Deprotected compounds 1 and 9 were allowed to react with 4,4'-dimethoxytrityl chloride in pyridine to give 5'-O-DMT nucleosides 2 and 10. The 3'-phosphoramidites 4 and 11 were incorporated into oligodeoxynucleosides (ODNs). The hybridization properties of the modified ODNs with their complementary DNA strands were studied. Interesting results were obtained when 11 was inserted as a bulged nucleoside into TWAs, duplexes, and triplexes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:28:35