Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Inhibition of neuronal nitric oxide synthase by N-phenacyl imidazoles
Autore:
Sorrenti, V; Di Giacomo, C; Salerno, L; Siracusa, MA; Guerrera, F; Vanella, A;
Indirizzi:
Univ Catania, Dept Biol Chem Med Chem & Mol Biol, I-95125 Catania, Italy Univ Catania Catania Italy I-95125 em & Mol Biol, I-95125 Catania, Italy Univ Catania, Dept Pharmaceut Sci, I-95125 Catania, Italy Univ Catania Catania Italy I-95125 harmaceut Sci, I-95125 Catania, Italy
Titolo Testata:
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
fascicolo: 1, volume: 5, anno: 2001,
pagine: 32 - 38
SICI:
1089-8603(200102)5:1<32:IONNOS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESCHERICHIA-COLI; RELAXING FACTOR; BINDING-SITES; TETRAHYDROBIOPTERIN; EXPRESSION; IDENTIFICATION; NEUROTOXICITY; MECHANISM; PATHWAY; BRAIN;
Keywords:
nNOS; selective inhibitors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Vanella, A Univ Catania, Dept Biol Chem Med Chem & Mol Biol, Vle A Doria 6, I-95125 Catania, Italy Univ Catania Vle A Doria 6 Catania Italy I-95125 atania, Italy
Citazione:
V. Sorrenti et al., "Inhibition of neuronal nitric oxide synthase by N-phenacyl imidazoles", NITRIC OXID, 5(1), 2001, pp. 32-38

Abstract

Nitric oxide (NO) mediates a series of physiological processes, including regulation of vascular tone, macrofage-mediated neurotoxicity, platelet aggregation, learning and long-term potentiation, and neuronal transmission. Although NO mediates several physiological functions, overproduction of NO can be detrimental and play multiple roles in several pathological diseases. Accordingly, more potent inhibitors, more selective for neuronal nitric oxide synthase (nNOS) than endothelial NOS (eNOS) or inducible NOS (iNOS), could be useful in the treatment of cerebral ischemia and other neurodegenerative diseases. We recently described the synthesis of a series of imidazolederivatives. Among them N-(4-nitrophenacyl) imidazole (A) and N-(4-nitrophenacyl)-2-methyl-imidazole (B) were considered selective nNOS inhibitors. In the present study the action mechanism of compounds A and E was analyzed. Spectral changes observed in the presence of compound A indicate that thisinhibitor exerts its effect without interaction with heme iron. Moreover compounds A and B, inhibit nNOS "noncompetitively" versus arginine, but "competitively" versus BH4. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:34:11