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Titolo:
Cloning of mouse BMAL2 and its daily expression profile in the suprachiasmatic nucleus: a remarkable acceleration of Bmal2 sequence divergence after Bmal gene duplication
Autore:
Okano, T; Sasaki, M; Fukada, Y;
Indirizzi:
Univ Tokyo, Grad Sch Sci, Dept Biophys & Biochem, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 Biochem, Bunkyo Ku, Tokyo 1130033, Japan Japan Sci & Technol Corp, CREST, Tokyo, Japan Japan Sci & Technol Corp Tokyo Japan Technol Corp, CREST, Tokyo, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 300, anno: 2001,
pagine: 111 - 114
SICI:
0304-3940(20010309)300:2<111:COMBAI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIRCADIAN CLOCK; CDNA CLONING; PROTEIN; MECHANISM; PACEMAKER;
Keywords:
BMAL; bHLH-PAS; gene duplication; circadian rhythm; suprachiasmatic nucleus; mouse; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Fukada, Y Univ Tokyo, Grad Sch Sci, Dept Biophys & Biochem, Bunkyo Ku, Hongo 7-3-1, Tokyo 1130033, Japan Univ Tokyo Hongo 7-3-1 Tokyo Japan 1130033 Tokyo 1130033, Japan
Citazione:
T. Okano et al., "Cloning of mouse BMAL2 and its daily expression profile in the suprachiasmatic nucleus: a remarkable acceleration of Bmal2 sequence divergence after Bmal gene duplication", NEUROSCI L, 300(2), 2001, pp. 111-114

Abstract

Brain-Muscle-Arnt-Like-protein 2 (BMAL2; Arnt4) (aryl hydrocarbon receptornuclear translocator) is a recently identified basic Helix-Loop-Helix-Per-Arnt-Sim (bHLH-PAS) transcription factor, which contributes to a positive regulation of autoregulatory feedback loop in vertebrate circadian clock systems. In this study, we cloned cDNAs encoding mouse and rat BMAL2 (mBMAL2 and rBMAL2) from mouse midbrain and rat-1 fibroblast cells, respectively. A phylogenetic analysis strongly suggested that vertebrate Bmal1 and Bmal2 genes were generated by a single gene duplication of an ancestral Bmal gene, a vertebrate ortholog of dCyc gene, and that 'BMAL2's putatively termed so far are orthologous. Interestingly, BMAL2 proteins have diverged about 20-fold more rapidly than BMAL1 proteins after the duplication, suggesting an as-yet-unidentified function conserved in BMAL1 but not in BMAL2. mBmal2 mRNA was constitutively expressed throughout the day under light-dark cycle inthe mouse hypothalamus containing suprachiasmatic nucleus, the site of thecentral circadian oscillator in mammals. (C) 2001 Elsevier Science IrelandLtd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 21:38:35