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Titolo:
The role of the chorda tympani nerve in the activation of the rat hypothalamic histaminergic system by leptin
Autore:
Morimoto-Ishizuka, T; Yamamoto, Y; Yamatodani, A;
Indirizzi:
Osaka Univ, Fac Med, Sch Allied Hlth Sci, Dept Med Phys, Osaka 5650871, Japan Osaka Univ Osaka Japan 5650871 Sci, Dept Med Phys, Osaka 5650871, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 300, anno: 2001,
pagine: 107 - 110
SICI:
0304-3940(20010309)300:2<107:TROTCT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURONAL HISTAMINE; WISTAR RATS; FOOD-INTAKE; RECEPTOR; MAMMALS; RELEASE; BRAIN; MICE;
Keywords:
leptin; histamine; the chorda tympani; microdialysis; hypothalamus; food intake;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Yamatodani, A Osaka Univ, Fac Med, Sch Allied Hlth Sci, Dept Med Phys, 1-7Yamadaoka, Osaka 5650871, Japan Osaka Univ 1-7 Yamadaoka Osaka Japan 5650871 5650871, Japan
Citazione:
T. Morimoto-Ishizuka et al., "The role of the chorda tympani nerve in the activation of the rat hypothalamic histaminergic system by leptin", NEUROSCI L, 300(2), 2001, pp. 107-110

Abstract

A possible pathway through which leptin activates the histaminergic systemwas studied using in vivo microdialysis in rats. Intraperitoneal injectionof leptin (1.3 mg/kg) caused a significant increase in hypothalamic histamine release, however, its intracerebroventricular injection (10 mug/rat) did not cause any significant changes in the release. Furthermore, leptin (1.3 mg/kg) had no effect on histamine release in rats whose chorda tympani nerves, a branch of the facial nerve which mediates taste information, were transected bilaterally. These findings indicate that leptin activates the histaminergic system by the peripheral signal inputs via the chorda tympani resulting in the suppression of food intake. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:35:49