Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Intrapallidal D-2 dopamine receptors control globus pallidus neuron activity in the rat
Autore:
Querejeta, E; Delgado, A; Valdiosera, R; Erlij, D; Aceves, J;
Indirizzi:
Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Fisiol Biofis & Neurociencias, Mexico City 07000, DF, Mexico Inst Politecn Nacl Mexico City DF Mexico 07000 ico City 07000, DF, Mexico Suny Downstate Med Ctr, Dept Physiol, Brooklyn, NY 11203 USA Suny Downstate Med Ctr Brooklyn NY USA 11203 siol, Brooklyn, NY 11203 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 300, anno: 2001,
pagine: 79 - 82
SICI:
0304-3940(20010309)300:2<79:IDDRCG>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASAL GANGLIA; GABA RELEASE; APOMORPHINE; ANESTHESIA; INHIBITION; BINDING; BRAIN;
Keywords:
basal ganglia; dopamine receptors; gamma-aminobutyric acid release and transmission; quinpirole; striatopallidal transmission; sulpiride;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Aceves, J Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept FisiolBiofis & Neurociencias, Apartado Postal 14140, Mexico City 07000, DF, Mexico Inst Politecn Nacl Apartado Postal 14140 Mexico City DF Mexico 07000
Citazione:
E. Querejeta et al., "Intrapallidal D-2 dopamine receptors control globus pallidus neuron activity in the rat", NEUROSCI L, 300(2), 2001, pp. 79-82

Abstract

Because activation of D-2 dopamine receptors inhibits gamma -aminobutyric acid (GABA) release from intrapallidal nerve terminals, we measured the effects of modifiers of dopamine D-2 receptors on the firing rate of single neurons in the globus pallidus (GP) of the anesthetized rat. The predominant effect of intrapallidal administration of the selective D-2 agonist quinpirole was an increase in the rate of spontaneous firing while the D-2 blockersulpiride caused a decrease. The spontaneous firing of GP neurons is inhibited by stimulation of the GABAergic striatopallidal projection. We therefore measured the effects of modifiers of D-2 receptors on striatal inhibition of GP neurons and found that intrapallidal quinpirole blocked the inhibitory effects of striatal stimulation while sulpiride enhanced them. These experiments show that both the spontaneous rate of firing of pallidal neuronsand its modification by striatopallidal inputs is controlled by intrapallidal dopamine D-2 receptors. In addition, taken together with other findingsin the literature, our results suggest that activation of dopamine D-2 receptors within the globus pallidus leads to inhibition of GABA release from presynaptic terminals. (C) 2001 Published by Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 22:56:40