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Titolo:
beta-amyloid peptide induces the expression of voltage dependent outward rectifying K+ channels in rat microglia
Autore:
Chung, S; Lee, J; Joe, EH; Uhm, DY;
Indirizzi:
Sung Kyun Kwan Univ, Sch Med, Dept Physiol, Suwon 440746, South Korea SungKyun Kwan Univ Suwon South Korea 440746 , Suwon 440746, South Korea Ajou Univ, Coll Med, Dept Pharmacol, Suwon 442749, South Korea Ajou Univ Suwon South Korea 442749 Pharmacol, Suwon 442749, South Korea
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 300, anno: 2001,
pagine: 67 - 70
SICI:
0304-3940(20010309)300:2<67:BPITEO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED MICROGLIA; POTASSIUM CHANNELS; CELLS;
Keywords:
antisense deoxyoligonucleotide; patch clamp; inward rectifier; Kv1.3; Kv1.5;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Chung, S Sung Kyun Kwan Univ, Sch Med, Dept Physiol, Suwon 440746, South Korea Sung Kyun Kwan Univ Suwon South Korea 440746 40746, South Korea
Citazione:
S. Chung et al., "beta-amyloid peptide induces the expression of voltage dependent outward rectifying K+ channels in rat microglia", NEUROSCI L, 300(2), 2001, pp. 67-70

Abstract

Upregulation of voltage-dependent outward rectifying K+ (Kv) channels has been reported in activated microglia. Since beta -amyloid peptide (A beta) is known to activate microglia, we tested whether the exposure of cultured rat microglia to A beta fragment 25-35 (A beta 25-35) induced the Ky current. AP 25-35 in 5-200 nM concentration range significantly increased Ky current density, while there was small change in inward rectifying K+ current density. The full length A beta peptide (A beta 1-42) also increased Ky current. However, the control peptide, A beta 35-25, did not induce Ky current. Most of the Ky current induced by A beta was specifically blocked by the presence of antisense deoxyoligonucleotides against Kv1.3, and Kv1.5. Thus, it is concluded that we have identified Kv1.3 and Kv1.5 as the channel types expressed in A beta -treated microglia. (C) 2001 Elsevier Science IrelandLtd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:31:59