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Titolo:
Successful trial of amantadine hydrochloride for two patients with alternating hemiplegia of childhood
Autore:
Sone, K; Oguni, H; Katsumori, H; Funatsuka, M; Tanaka, T; Osawa, M;
Indirizzi:
Tokyo Womens Med Univ, Dept Pediat, Shinjuku Ku, Tokyo 162, Japan Tokyo Womens Med Univ Tokyo Japan 162 iat, Shinjuku Ku, Tokyo 162, Japan
Titolo Testata:
NEUROPEDIATRICS
fascicolo: 6, volume: 31, anno: 2000,
pagine: 307 - 309
SICI:
0174-304X(200012)31:6<307:STOAHF>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHLORAL HYDRATE; FLUNARIZINE; MEMANTINE;
Keywords:
amantadine; memantine; alternating hemiplegia; non-competitive NMDA receptor antagonist;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Oguni, H Tokyo Womens Med Univ, Dept Pediat, Shinjuku Ku, 8-1 Kawada Cho, Tokyo 162, Japan Tokyo Womens Med Univ 8-1 Kawada Cho Tokyo Japan 162 162, Japan
Citazione:
K. Sone et al., "Successful trial of amantadine hydrochloride for two patients with alternating hemiplegia of childhood", NEUROPEDIAT, 31(6), 2000, pp. 307-309

Abstract

We report here the efficacy of amantadine hydrochloride for two patients with alternating hemiplegia of childhood (AHC) that did not respond to flunarizine. Amantadine was administered to one patient at age one year and seven months and to the other at age 25 years. The frequencies and duration of the hemiplegic attacks significantly improved in both patients. However, the attacks gradually returned to the previous level after a significant reduction in seizures for three years in the younger patient with ongoing AHC. Our therapeutic results further support the hypothesis that glutamate and NMDA receptors are involved in inducing alternating hemiplegic attacks, because amantadine as well as its derivative, memantine, are clinically available non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, with neuroprotective effects. Amantadine is worth trying when treating patients with AHC as a first trial or a substitute for flunarizine once the latter agent looses effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:20:47