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Titolo:
Lesions of the dorsomedial hypothalamic nucleus do not influence the dailyprofile of pineal metabolism in rats
Autore:
Mota, SR; Canteras, NS; Bartol, I; Skorupa, AL; Scialfa, JH; Terra, IM; Afeche, SC; Cipolla-Neto, J;
Indirizzi:
Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508900 Sao Paulo, SP, Brazil Univ Sao Paulo Sao Paulo SP Brazil BR-05508900 BC00 Sao Paulo, SP, Brazil Inst Butantan, Pharmacol Lab, Sao Paulo, Brazil Inst Butantan Sao Paulo Brazil tantan, Pharmacol Lab, Sao Paulo, Brazil
Titolo Testata:
NEUROENDOCRINOLOGY
fascicolo: 2, volume: 73, anno: 2001,
pagine: 123 - 128
SICI:
0028-3835(200102)73:2<123:LOTDHN>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPRACHIASMATIC NUCLEUS; N-ACETYLTRANSFERASE; EFFERENT PROJECTIONS; RETROCHIASMATIC AREA; MELATONIN; LIGHT; ORGANIZATION; TRANSPORT; NIGHT; CONNECTIONS;
Keywords:
dorsomedial hypothalamic nucleus; melatonin; N-acetylserotonin; serotonin; pineal gland; circadian rhythms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Cipolla-Neto, J Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Av Lineu Prestes,1524,Bldg 1, BR-05508900 Sao Paulo, SP, Brazil Univ Sao Paulo Av Lineu Prestes,1524,Bldg 1 Sao Paulo SP Brazil BR-05508900 BC
Citazione:
S.R. Mota et al., "Lesions of the dorsomedial hypothalamic nucleus do not influence the dailyprofile of pineal metabolism in rats", NEUROENDOCR, 73(2), 2001, pp. 123-128

Abstract

The present study attempted to characterize the effects of electrolytic lesions of the hypothalamic dorsomedial nucleus on the daily profile of pineal metabolism as well as on the inhibition of pineal melatonin synthesis induced by acute light exposure during the night. Adult male Wistar rats (n = 107, 12:12 h light-dark cycle) were left intact (n = 47) or lesioned (n = 60). Lesioned rats and their respective controls were killed at six time points distributed throughout the light-dark cycle. At ZT (zeitgeber time) 18 the animals were killed either in the dark or after 15 min of light stimulation. Pineal glands were assayed using high-performance liquid chromatography with electrochemical detection (HPLC-ED). There was no difference in theamounts of pineal indoles between lesioned and control rats under any of the experimental situations tested. These results suggest that in rats, the hypothalamic dorsomedial nucleus does not participate in either the neural control of daily pineal metabolism or the nocturnal light-induced inhibition of the pineal metabolism. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:30:02