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Titolo:
Effect of dexmedetomidine on the release of [H-3]-noradrenaline from rat kidney cortex slices: characterization of alpha(2)-adrenoceptor
Autore:
Taoda, M; Adachi, YU; Uchihashi, Y; Watanabe, K; Satoh, T; Vizi, ES;
Indirizzi:
Hungarian Acad Sci, Inst Expt Med, Dept Pharmacol, H-1450 Budapest, Hungary Hungarian Acad Sci Budapest Hungary H-1450 col, H-1450 Budapest, Hungary Natl Def Med Coll, Dept Anesthesiol, Tokorozawa, Saitama 3598513, Japan Natl Def Med Coll Tokorozawa Saitama Japan 3598513 Saitama 3598513, Japan
Titolo Testata:
NEUROCHEMISTRY INTERNATIONAL
fascicolo: 4, volume: 38, anno: 2001,
pagine: 317 - 322
SICI:
0197-0186(200104)38:4<317:EODOTR>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIARTERIAL NERVE-STIMULATION; NOREPINEPHRINE RELEASE; ALPHA-2 ADRENOCEPTORS; NORADRENALINE RELEASE; ADRENERGIC-RECEPTOR; MODULATION; SUBTYPES; TRANSMITTER; ANTAGONIST; AGONIST;
Keywords:
dexmedetomidine; alpha(2)-adrenoceptor; rat kidney cortex slices;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Vizi, ES Hungarian Acad Sci, Inst Expt Med, Dept Pharmacol, POB 67, H-1450Budapest, Hungary Hungarian Acad Sci POB 67 Budapest Hungary H-1450 apest, Hungary
Citazione:
M. Taoda et al., "Effect of dexmedetomidine on the release of [H-3]-noradrenaline from rat kidney cortex slices: characterization of alpha(2)-adrenoceptor", NEUROCHEM I, 38(4), 2001, pp. 317-322

Abstract

The presynaptic modulation of [H-3]-noradrenaline (NA) release from rat kidney cortex slices, a method used for the first time, was investigated. Ratkidney cortex slices were loaded with [H-3]-NA and the release of radioactivity at rest and in response to field stimulation was determined. The alpha (2)-adrenoceptor agonist, dexmedetomidine inhibited the stimulation-evoked release of NA from kidney slices in a concentration-dependent manner, whereas alpha (2)-adrenoceptor antagonist CH-38083 (7,8-methyenedioxy-14-alpha-hydroxyalloberbane HCl), an alpha (2)-adrenoceptor antagonists, enhanced it. When dexmedetomidine and BRL-44408, a selective alpha (2A) antagonist, were added together, the effect of dexmedetomidine was significantly antagonized. In contrast, ARC-239 (2-(2,4-(o-piperazine-1- yl)-ethyl-4,4-dimethyl-1,3-(2H, 4H)disoguinolinedione chloride), a selective alpha (2B)-antagonist, had no effect on the release and failed to prevent the effect of dexmedetomidine. Prazosin, an alpha (1)- and alpha (2B/C)-adrenoceptor antagonist enhanced the release evoked by field stimulation. It is therefore suggested that there is a negative feedback modulation of NA release at the sympathetic innervation of kidney cortex, and dexmedetomidine, a clinically used anesthetic adjunct inhibits the release via activation of alpha (2C)-adrenoceptors. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:53:31