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Titolo:
Learning and memory in S100-beta transgenic mice: An analysis of impaired and preserved function
Autore:
Winocur, G; Roder, J; Lobaugh, N;
Indirizzi:
Baycrest Ctr Geriatr Care, Rotman Res Inst, Toronto, ON M6A 2E1, Canada Baycrest Ctr Geriatr Care Toronto ON Canada M6A 2E1 o, ON M6A 2E1, Canada Trent Univ, Dept Psychol, Peterborough, ON K9J 7B8, Canada Trent Univ Peterborough ON Canada K9J 7B8 eterborough, ON K9J 7B8, Canada Univ Toronto, Dept Psychol, Toronto, ON M5S 1A1, Canada Univ Toronto Toronto ON Canada M5S 1A1 ychol, Toronto, ON M5S 1A1, Canada Univ Toronto, Dept Psychiat, Toronto, ON M5S 1A1, Canada Univ Toronto Toronto ON Canada M5S 1A1 chiat, Toronto, ON M5S 1A1, Canada Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp Toronto ON Canada M5G 1X5 Inst, Toronto, ON M5G 1X5, Canada
Titolo Testata:
NEUROBIOLOGY OF LEARNING AND MEMORY
fascicolo: 2, volume: 75, anno: 2001,
pagine: 230 - 243
SICI:
1074-7427(200103)75:2<230:LAMIST>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
MATCHING-TO-SAMPLE; PREFRONTAL CORTEX; HIPPOCAMPAL-LESIONS; CAUDATE-NUCLEUS; WORKING-MEMORY; ALZHEIMER-TYPE; DORSAL HIPPOCAMPAL; RETROGRADE-AMNESIA; THALAMIC LESIONS; MAZE BEHAVIOR;
Keywords:
S100-beta; transgenic mice; learning and memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Winocur, G Baycrest Ctr Geriatr Care, Rotman Res Inst, 3560 Bathurst St, Toronto, ON M6A 2E1, Canada Baycrest Ctr Geriatr Care 3560 Bathurst St Toronto ON Canada M6A 2E1
Citazione:
G. Winocur et al., "Learning and memory in S100-beta transgenic mice: An analysis of impaired and preserved function", NEUROBIOL L, 75(2), 2001, pp. 230-243

Abstract

S100-beta, a calcium-binding astrocytic protein from chromosome 21, has been implicated in CNS function generally and the hippocampus in particular. Elevated levels of S 100-beta have been observed reliably in the brains of patients with Alzheimer's Disease and Down Syndrome. Groups of transgenic mice, carrying multiple S100-beta gene copies, and nontransgenic controls were administered a series of behavioral tests (delayed spatial and nonspatial non-matching-to-sample, radial arm maze, socially acquired food preference) that assessed a wide range of cognitive functions. Consistent with the widespread presence of S100-beta throughout the brain, transgenic mice exhibited learning or memory impairment on all tasks. The dementia-like cognitive profile of S100-beta mice represents a promising model for studying comparable cognitive deficits associated with neurodegenerative diseases. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:19:55