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Titolo:
Glucose treatment reduces memory deficits in young adult rats fed high-fatdiets
Autore:
Greenwood, CE; Winocur, G;
Indirizzi:
Univ Toronto, Dept Nutr Sci, Fac Med, Toronto, ON M5S 2E3, Canada Univ Toronto Toronto ON Canada M5S 2E3 c Med, Toronto, ON M5S 2E3, Canada Baycrest Ctr Geriatr Care, Kunin Lunenfeld Appl Res Unit, Toronto, ON, Canada Baycrest Ctr Geriatr Care Toronto ON Canada es Unit, Toronto, ON, Canada Baycrest Ctr Geriatr Care, Dept Food & Nutr Serv, Toronto, ON, Canada Baycrest Ctr Geriatr Care Toronto ON Canada tr Serv, Toronto, ON, Canada Baycrest Ctr Geriatr Care, Rotman Res Inst, Toronto, ON, Canada Baycrest Ctr Geriatr Care Toronto ON Canada es Inst, Toronto, ON, Canada Trent Univ, Dept Psychol, Peterborough, ON K9J 7B8, Canada Trent Univ Peterborough ON Canada K9J 7B8 eterborough, ON K9J 7B8, Canada Univ Toronto, Dept Psychol, Toronto, ON M5S 1A1, Canada Univ Toronto Toronto ON Canada M5S 1A1 ychol, Toronto, ON M5S 1A1, Canada Univ Toronto, Dept Psychiat, Toronto, ON, Canada Univ Toronto Toronto ON Canada ronto, Dept Psychiat, Toronto, ON, Canada
Titolo Testata:
NEUROBIOLOGY OF LEARNING AND MEMORY
fascicolo: 2, volume: 75, anno: 2001,
pagine: 179 - 189
SICI:
1074-7427(200103)75:2<179:GTRMDI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPAL ACETYLCHOLINE-RELEASE; AGED RATS; COGNITIVE PERFORMANCE; ALZHEIMERS-DISEASE; GLYCEMIC CONTROL; INSULIN; IMPROVEMENT; MODULATION; IMPAIRMENT; LIPIDS;
Keywords:
learning; dietary fat; insulin resistance; diabetes; saturated fatty acids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Greenwood, CE Univ Toronto, Dept Nutr Sci, Fac Med, Toronto, ON M5S 2E3, Canada Univ Toronto Toronto ON Canada M5S 2E3 , ON M5S 2E3, Canada
Citazione:
C.E. Greenwood e G. Winocur, "Glucose treatment reduces memory deficits in young adult rats fed high-fatdiets", NEUROBIOL L, 75(2), 2001, pp. 179-189

Abstract

Feeding rats high-fat diets for 7 months produces a widespread cognitive deficit that affects performance on a wide range of learning and memory tasks. The present study tested the hypothesis that this effect is related to afat-induced impairment in glucose metabolism. Following 3 months of dietary intervention (20% by weight fat diets, composed primarily of either beef tallow or soybean oil versus standard laboratory chow), male Long-Evans rats were tested on a variable interval delayed alternation (VIDA) task that measures learning and memory functions that differentially involve specific brain regions. Relative to rats fed chow, rats consuming the high-fat dietswere impaired on all aspects of VIDA performance. Following baseline testing, rats were maintained on their respective diets and the effect of glucose administration (100 mg/kg BW; i.p.) was examined. For the next 6 days, animals alternately received injections of saline or glucose 30 min prior to VIDA testing. Glucose treatment improved performance, with the effect beingmost pronounced at the longer intertrial intervals where task performance is sensitive to hippocampal impairment. Importantly, the beneficial effect of glucose were confined to those animals consuming the high-fat diets and were not observed in rats fed chow. These results demonstrate that glucose administration can overcome those deficits associated with hippocampal function in rats fed high-fat diets and are consistent with the hypothesis thathigh-fat diets, in part, mediate their effect through the development of insulin resistance and glucose intolerance. (C) 2001 Academic Press.

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Documento generato il 09/04/20 alle ore 12:11:51