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Titolo:
Properties of synaptic transmission and the global stability of delayed activity states
Autore:
Koulakov, AA;
Indirizzi:
Salk Inst, La Jolla, CA 92037 USA Salk Inst La Jolla CA USA 92037Salk Inst, La Jolla, CA 92037 USA
Titolo Testata:
NETWORK-COMPUTATION IN NEURAL SYSTEMS
fascicolo: 1, volume: 12, anno: 2001,
pagine: 47 - 74
SICI:
0954-898X(200102)12:1<47:POSTAT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONCOMPETITIVE NMDA ANTAGONIST; PRIMATE TEMPORAL CORTEX; LONG-TERM-MEMORY; LOW SPIKE RATES; WORKING-MEMORY; PREFRONTAL CORTEX; ASYNCHRONOUS STATES; NEURONAL CORRELATE; NEURAL NETWORKS; TIME COURSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Engineering, Computing & Technology
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Koulakov, AA Salk Inst, La Jolla, CA 92037 USA Salk Inst La Jolla CA USA 92037 Inst, La Jolla, CA 92037 USA
Citazione:
A.A. Koulakov, "Properties of synaptic transmission and the global stability of delayed activity states", NETWORK-COM, 12(1), 2001, pp. 47-74

Abstract

The influence of synaptic channel properties on the stability of delayed activity maintained by recurrent neural networks is studied. The duration ofexcitatory post-synaptic current (EPSC) is shown to be essential for the global stability of the delayed response. The NMDA receptor channel is a much more reliable mediator of the reverberating activity than the AMPA receptor, due to a longer EPSC. This allows one to interpret the deterioration ofthe working memory observed in NMDA channel blockade experiments. The key mechanism leading to the decay of the delayed activity originates in the unreliability of synaptic transmission. The optimum fluctuation of the synaptic currents leading to the decay is identified. The decay time is calculated analytically and the result is confirmed computationally.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/10/20 alle ore 11:07:56