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Titolo:
Immunohistochemical detection of telomerase (hTERT) protein in human cancer tissues and a subset of cells in normal tissues
Autore:
Hiyama, E; Hiyama, K; Yokoyama, T; Shay, JW;
Indirizzi:
Univ Texas, SW Med Ctr, Dept Cell Biol, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 Ctr, Dept Cell Biol, Dallas, TX 75390 USA Hiroshima Univ, Sch Med, Dept Internal Med 2, Hiroshima, Japan Hiroshima Univ Hiroshima Japan d, Dept Internal Med 2, Hiroshima, Japan Hiroshima Univ, Sch Med, Dept Gen Med, Hiroshima, Japan Hiroshima Univ Hiroshima Japan Sch Med, Dept Gen Med, Hiroshima, Japan
Titolo Testata:
NEOPLASIA
fascicolo: 1, volume: 3, anno: 2001,
pagine: 17 - 26
SICI:
1522-8002(200101/02)3:1<17:IDOT(P>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
REVERSE-TRANSCRIPTASE HTERT; PROGNOSTIC INDICATOR; RNA COMPONENT; NEUROBLASTOMA; GENE; AMPLIFICATION; TUMORS;
Keywords:
telomerase; immunohistochemistry; hTERT; cancer; human;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Shay, JW Univ Texas, SW Med Ctr, Dept Cell Biol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75390 TX 75390 USA
Citazione:
E. Hiyama et al., "Immunohistochemical detection of telomerase (hTERT) protein in human cancer tissues and a subset of cells in normal tissues", NEOPLASIA, 3(1), 2001, pp. 17-26

Abstract

We examined human telomerase reverse transcriptase (hTERT) protein distribution by immunohistochemistry in cultured cells and tissue sections. Cells with telomerase activity had nuclear positive signals whereas cells withouttelomerase activity did not, In most normal epithelial tissues, hTERT expression was prominent in the early proliferative descendent progenitor cells. In cancers with high telomerase activity, hTERT expression was detected in almost ail neoplastic cells and correlated with telomerase activity levels, whereas cancers with low telomerase activity had fewer hTERT-positive cancer cells. In pediatric neuroblastomas with a favorable outcome, both the percentage of positive cells and the signal intensity of each hTERT-expressing cell decreased. These studies indicate that detection of telomerase at the cellular level is achievable and may have utility in cancer diagnostics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 01:47:36