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Titolo:
Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis
Autore:
Kato, T; Satoh, S; Okabe, H; Kitahara, O; Ono, K; Kihara, C; Tanaka, T; Tsunoda, T; Yamaoka, Y; Nakamura, Y; Furukawa, Y;
Indirizzi:
Univ Tokyo, Inst Med Sci, Mol Med Lab, Minato Ku, Tokyo 1088639, Japan Univ Tokyo Tokyo Japan 1088639 Med Lab, Minato Ku, Tokyo 1088639, Japan Kyoto Univ, Grad Sch Med, Dept Surg Gastroenterol, Kyoto, Japan Kyoto Univ Kyoto Japan d Sch Med, Dept Surg Gastroenterol, Kyoto, Japan RIKEN, Inst Phys & Chem Res, SNP Res Ctr, Tokyo, Japan RIKEN Tokyo Japan IKEN, Inst Phys & Chem Res, SNP Res Ctr, Tokyo, Japan
Titolo Testata:
NEOPLASIA
fascicolo: 1, volume: 3, anno: 2001,
pagine: 4 - 9
SICI:
1522-8002(200101/02)3:1<4:IOANHG>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-CATENIN MUTATIONS; COLON-CARCINOMA; HUMAN CDC25C; ACTIVATION; CANCER; EXPRESSION; PATHWAY; TARGET; CELLS; APC;
Keywords:
MARKL1; beta-catenin; microarray; expression profile; hepatocellular carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Nakamura, Y Univ Tokyo, Inst Med Sci, Mol Med Lab, Minato Ku, 4-6-1 Shirokanedai, Tokyo 1088639, Japan Univ Tokyo 4-6-1 Shirokanedai Tokyo Japan 1088639 8639, Japan
Citazione:
T. Kato et al., "Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis", NEOPLASIA, 3(1), 2001, pp. 4-9

Abstract

Activation of the Wnt-signaling pathway is known to play a crucial role incarcinogenesis of various human organs including the colon, liver, prostate, and endometrium, To investigate the mechanisms underlying hepatocellularcarcinogenesis, we attempted to identify genes regulated by beta -catenin/Tcf complex in a human hepatoma cell line, HepG2, in which an activated form of beta -catenin is expressed, By means of cDNA microarray, we isolated anovel human gene, termed MARKL1 (MAP/microtubule affinity-regulating kinase-like 1), whose expression was downregulated in response to decreased Tcf/LEF1 activity, The transcript expressed in liver consisted of 3529 nucleotides that contained an open reading frame of 2256 nucleotides, encoding 752 amino acids homologous to human MARKS (MAP/ microtubule affinity-regulatingkinase 3), Expression levels of MARKL1 were markedly elevated in eight of nine HCCs in which nuclear accumulation of beta -catenin was observed, which may suggest that MARKL1 plays some role in hepatocellular carcinogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:44:44