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Titolo:
Modifier genes in mice and humans
Autore:
Nadeau, JH;
Indirizzi:
Case Western Reserve Univ, Sch Med, Dept Genet, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Univ Hosp Cleveland, Ctr Human Genet, Cleveland, OH 44106 USA Univ Hosp Cleveland Cleveland OH USA 44106 Genet, Cleveland, OH 44106 USA
Titolo Testata:
NATURE REVIEWS GENETICS
fascicolo: 3, volume: 2, anno: 2001,
pagine: 165 - 174
SICI:
1471-0056(200103)2:3<165:MGIMAH>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURAL-TUBE DEFECTS; GENETICS REVOLUTIONIZE MEDICINE; MULTIPLE INTESTINAL NEOPLASIA; FAMILIAL MEDITERRANEAN FEVER; APC(DELTA-716) KNOCKOUT MICE; CYSTIC-FIBROSIS; DILUTE SUPPRESSOR; MAJOR MODIFIER; SPINA-BIFIDA; MUTANT MICE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: Nadeau, JH Case Western Reserve Univ, Sch Med, Dept Genet, 10,900 Euclid Ave, Cleveland, OH 44106 USA Case Western Reserve Univ 10,900 Euclid Ave Cleveland OH USA 44106
Citazione:
J.H. Nadeau, "Modifier genes in mice and humans", NAT REV GEN, 2(3), 2001, pp. 165-174

Abstract

An emerging theme of studies with spontaneous, engineered and induced mutant mice is that phenotypes often depend on genetic background, implying that genetic modifiers have a role in guiding the functional consequences of genetic variation. Understanding the molecular and cellular basis by which modifier genes exert their influence will provide insights into developmental and physiological pathways that are critical to fundamental biological processes, as well as into novel targets for therapeutic interventions in human diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 06:53:18