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Titolo:
Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability
Autore:
Chen, K; Aradi, I; Thon, N; Eghbal-Ahmadi, M; Baram, TZ; Soltesz, I;
Indirizzi:
Univ Calif Irvine, Dept Anat & Neurobiol, Irvine, CA 92717 USA Univ Calif Irvine Irvine CA USA 92717 t & Neurobiol, Irvine, CA 92717 USA Univ Calif Irvine, Dept Pediat, Irvine, CA 92717 USA Univ Calif Irvine Irvine CA USA 92717 , Dept Pediat, Irvine, CA 92717 USA
Titolo Testata:
NATURE MEDICINE
fascicolo: 3, volume: 7, anno: 2001,
pagine: 331 - 337
SICI:
1078-8956(200103)7:3<331:PMHACF>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL-LOBE EPILEPSY; HYPERPOLARIZATION-ACTIVATED CURRENT; CA1 PYRAMIDAL NEURONS; CURRENT I-H; PACEMAKER CHANNELS; GUINEA-PIG; HIPPOCAMPAL-NEURONS; GABA(A) RECEPTORS; DEVELOPING BRAIN; INCREASED NUMBER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Soltesz, I Univ Calif Irvine, Dept Anat & Neurobiol, Irvine, CA 92717 USA Univ Calif Irvine Irvine CA USA 92717 ol, Irvine, CA 92717 USA
Citazione:
K. Chen et al., "Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability", NAT MED, 7(3), 2001, pp. 331-337

Abstract

Febrile seizures are the most common type of developmental seizures, affecting up to 5% of children. Experimental complex febrile seizures involving the immature rat hippocampus led to a persistent lowering of seizure threshold despite an upregulation of inhibition. Here we provide a mechanistic resolution to this paradox by showing that, in the hippocampus of rats that had febrile seizures, the long-lasting enhancement of the widely expressed intrinsic: membrane conductance I-h converts the potentiated synaptic inhibition to hyperexcitability in a frequency-dependent manner. The altered gainof this molecular inhibition-excitation converter reveals a new mechanism for controlling the balance of excitation-inhibition in the limbic system. In addition, here we show for the first time that h-channels are modified in a human neurological disease paradigm.

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Documento generato il 22/01/20 alle ore 07:00:07