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Titolo:
ORP150 protects against hypoxia/ischemia-induced neuronal death
Autore:
Tamatani, M; Matsuyama, T; Yamaguchi, A; Mitsuda, N; Tsukamoto, Y; Taniguchi, M; Che, YH; Ozawa, K; Hori, O; Nishimura, H; Yamashita, A; Okabe, M; Yanagi, H; Stern, DM; Ogawa, S; Tohyama, M;
Indirizzi:
Osaka Univ, Grad Sch Med, Dept Anat & Neurosci, Osaka, Japan Osaka Univ Osaka Japan Grad Sch Med, Dept Anat & Neurosci, Osaka, Japan Hyogo Coll Med, Dept Internal Med 5, Hyogo, Japan Hyogo Coll Med Hyogo Japan Coll Med, Dept Internal Med 5, Hyogo, Japan Natl Ctr Cardiac Dis & Circulat Res, Dept Pathol, Osaka, Japan Natl Ctr Cardiac Dis & Circulat Res Osaka Japan pt Pathol, Osaka, Japan Kanazawa Univ, Sch Med, Dept Neuroanat, Kanazawa, Ishikawa 920, Japan Kanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan HSP Res Inst, Kyoto, Japan HSP Res Inst Kyoto JapanHSP Res Inst, Kyoto, Japan Osaka Univ, Genome Informat Res Ctr, Osaka, Japan Osaka Univ Osaka Japan saka Univ, Genome Informat Res Ctr, Osaka, Japan Columbia Univ, Coll Phys & Surg, CREST, JST, New York, NY USA Columbia Univ New York NY USA Phys & Surg, CREST, JST, New York, NY USA Columbia Univ, Coll Phys & Surg, Dept Physiol & Cellular Biophys, New York, NY USA Columbia Univ New York NY USA ysiol & Cellular Biophys, New York, NY USA
Titolo Testata:
NATURE MEDICINE
fascicolo: 3, volume: 7, anno: 2001,
pagine: 317 - 323
SICI:
1078-8956(200103)7:3<317:OPAHND>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL CEREBRAL-ISCHEMIA; CENTRAL-NERVOUS-SYSTEM; APOPTOTIC CELL-DEATH; NF-KAPPA-B; ENDOPLASMIC-RETICULUM; NEUROTROPHIC FACTOR; CYTOCHROME-C; RAT-BRAIN; EXPRESSION; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Tamatani, M Osaka Univ, Grad Sch Med, Dept Anat & Neurosci, Osaka, Japan Osaka Univ Osaka Japan , Dept Anat & Neurosci, Osaka, Japan
Citazione:
M. Tamatani et al., "ORP150 protects against hypoxia/ischemia-induced neuronal death", NAT MED, 7(3), 2001, pp. 317-323

Abstract

Oxygen-regulated protein 150 kD (ORP150) is a novel endoplasmic-reticulum-associated chaperone induced by hypoxia/ischemia. Although ORP150 was sparingly upregulated in neurons from human brain undergoing ischemic stress, there was robust induction in astrocytes. Cultured neurons overexpressing ORP150 were resistant to hypoxemic stress, whereas astrocytes with inhibited ORP150 expression were more vulnerable. Mice with targeted neuronal overexpression of ORP150 had smaller strokes compared with controls. Neurons with increased ORP150 demonstrated suppressed caspase-3-like activity and enhanced brain-derived neurotrophic factor (BDNF) under hypoxia signaling. These data indicate that ORP150 is an integral participant in ischemic cytoprotective pathways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:17:26