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Titolo:
Selection for transgene homozygosity in embryonic stem cells results in extensive loss of heterozygosity
Autore:
Lefebvre, L; Dionne, N; Karaskova, J; Squire, JA; Nagy, A;
Indirizzi:
Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp Toronto ON Canada M5G 1X5 Inst, Toronto, ON M5G 1X5, Canada Univ Toronto, Dept Med Genet, Toronto, ON M5G 1X5, Canada Univ Toronto Toronto ON Canada M5G 1X5 Genet, Toronto, ON M5G 1X5, Canada
Titolo Testata:
NATURE GENETICS
fascicolo: 3, volume: 27, anno: 2001,
pagine: 257 - 258
SICI:
1061-4036(200103)27:3<257:SFTHIE>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICE; LACKING; ALLELE;
Tipo documento:
Letter
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Lefebvre, L Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5,Canada Mt Sinai Hosp Toronto ON Canada M5G 1X5 o, ON M5G 1X5, Canada
Citazione:
L. Lefebvre et al., "Selection for transgene homozygosity in embryonic stem cells results in extensive loss of heterozygosity", NAT GENET, 27(3), 2001, pp. 257-258

Abstract

Embryonic stem cells offer unprecedented opportunities for random or targeted genome alterations in the mouse. We present here an efficient strategy to create chromosome-specific loss of heterozygosity in embryonic stem cells. The combination of this method with genome-wide mutagenesis in ES cells (using chemical mutagens or gene-trap vectors) opens up the possibility forin vitro or in vivo functional screening of recessive mutations in the mouse.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:41:52