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Titolo:
DNA replication control through interaction of E2F-RB and the origin recognition complex
Autore:
Bosco, G; Du, W; Orr-Weaver, TL;
Indirizzi:
MIT, Whitehead Inst Biomed Res, Cambridge, MA 02142 USA MIT Cambridge MA USA 02142 ehead Inst Biomed Res, Cambridge, MA 02142 USA MIT, Dept Biol, Cambridge, MA 02142 USA MIT Cambridge MA USA 02142MIT, Dept Biol, Cambridge, MA 02142 USA Univ Chicago, Ben May Inst Canc Res, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 ay Inst Canc Res, Chicago, IL 60637 USA Univ Chicago, Ctr Mol Oncol, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 o, Ctr Mol Oncol, Chicago, IL 60637 USA
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 3, volume: 3, anno: 2001,
pagine: 289 - 295
SICI:
1465-7392(200103)3:3<289:DRCTIO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
S-PHASE COMPLETION; CELL-CYCLE CONTROL; RETINOBLASTOMA PROTEIN; HISTONE DEACETYLASE; DROSOPHILA-MELANOGASTER; REPRESS TRANSCRIPTION; GENE AMPLIFICATION; DISTINCT ROLES; EMBRYOGENESIS; MUTATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Orr-Weaver, TL MIT, Whitehead Inst Biomed Res, Cambridge, MA 02142 USA MIT Cambridge MA USA 02142 ed Res, Cambridge, MA 02142 USA
Citazione:
G. Bosco et al., "DNA replication control through interaction of E2F-RB and the origin recognition complex", NAT CELL BI, 3(3), 2001, pp. 289-295

Abstract

The E2F transcription factor and retinoblastoma protein control cell-cycleprogression and DNA replication during S phase. Mutations in the Drosophila dE2F1 and dDP genes affect the origin recognition complex (DmORC) and initiation of replication at the chorion gene replication origin. Here we showthat mutants of Rbf (an retinoblastoma protein homologue) fail to limit DNA replication. We also show that the dDP, dE2F1 and Rbf proteins are located in a complex with DmORC, and that dE2F1 and DmORC are bound to the chorion origin of replication in vivo. Our results indicate that dE2F1 and Rbf function together at replication origins to limit DNA replication through interactions with DmORC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:55:47