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Titolo:
Filovirus-pseudotyped lentiviral vector can efficiently and stably transduce airway epithelia in vivo
Autore:
Kobinger, GP; Weiner, DJ; Yu, QC; Wilson, JM;
Indirizzi:
Univ Penn Hlth Syst, Inst Human Gene Therapy, Philadelphia, PA 19104 USA Univ Penn Hlth Syst Philadelphia PA USA 19104 Philadelphia, PA 19104 USA Univ Penn Hlth Syst, Dept Mol & Cellular Engn, Philadelphia, PA 19104 USA Univ Penn Hlth Syst Philadelphia PA USA 19104 Philadelphia, PA 19104 USA Childrens Hosp Philadelphia, Div Pulm Med, Philadelphia, PA 19104 USA Childrens Hosp Philadelphia Philadelphia PA USA 19104 lphia, PA 19104 USA
Titolo Testata:
NATURE BIOTECHNOLOGY
fascicolo: 3, volume: 19, anno: 2001,
pagine: 225 - 230
SICI:
1087-0156(200103)19:3<225:FLVCEA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIATED GENE-TRANSFER; HUMAN BRONCHIAL EPITHELIA; CYSTIC-FIBROSIS; EBOLA-VIRUS; ENVELOPE GLYCOPROTEINS; ADENOASSOCIATED VIRUS; FUSION PROTEINS; CELL-LINES; RETROVIRUS; XENOGRAFTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Wilson, JM Univ Penn Hlth Syst, Inst Human Gene Therapy, Philadelphia, PA 19104 USA Univ Penn Hlth Syst Philadelphia PA USA 19104 ia, PA 19104 USA
Citazione:
G.P. Kobinger et al., "Filovirus-pseudotyped lentiviral vector can efficiently and stably transduce airway epithelia in vivo", NAT BIOTECH, 19(3), 2001, pp. 225-230

Abstract

Traditional gene therapy vectors have demonstrated limited utility for treatment of chronic lung diseases such as cystic fibrosis (CF). Herein we describe a vector based on a Filovirus envelope protein-pseudotyped HIV vector, which we chose after systematically evaluating multiple strategies. The vector efficiently transduces intact airway epithelium from the apical surface, as demonstrated in both in vitro and in vivo model systems. This shows the potential of pseudotyping in expanding the utility of lentiviral vectors. Pseudotyped lentiviral vectors may hold promise for the treatment of CF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:17:36