Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A test of the mutagenicity of cooked meats in vivo
Autore:
Heddle, JA; Knize, MG; Dawod, D; Zhang, XB;
Indirizzi:
York Univ, Dept Biol, Toronto, ON M3J 1J3, Canada York Univ Toronto ON Canada M3J 1J3 ept Biol, Toronto, ON M3J 1J3, Canada Univ Calif Lawrence Livermore Natl Lab, Livermore, CA 94551 USA Univ CalifLawrence Livermore Natl Lab Livermore CA USA 94551 A 94551 USA Apotex Pharmaceut, Weston, ON M9L 1T9, Canada Apotex Pharmaceut Weston ONCanada M9L 1T9 ut, Weston, ON M9L 1T9, Canada
Titolo Testata:
MUTAGENESIS
fascicolo: 2, volume: 16, anno: 2001,
pagine: 103 - 107
SICI:
0267-8357(200103)16:2<103:ATOTMO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LACI TRANSGENIC MICE; HETEROCYCLIC AMINES; IN-VIVO; SOMATIC MUTATION; SMALL-INTESTINE; STEM-CELLS; CANCER; CARCINOGENICITY; COLON; FOOD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Heddle, JA York Univ, Dept Biol, Toronto, ON M3J 1J3, Canada York Univ Toronto ON Canada M3J 1J3 oronto, ON M3J 1J3, Canada
Citazione:
J.A. Heddle et al., "A test of the mutagenicity of cooked meats in vivo", MUTAGENESIS, 16(2), 2001, pp. 103-107

Abstract

There is a correlation between intestinal cancer and diets high in meat, so fried beef, chicken, lamb, pork and fish were tested for their ability toinduce mutations in the small intestine of mice, The mice were bred to be heterozygous at the Dlb-1 locus so that loss of the dominant Dlb-1(b) allele by mutation could be detected, Mice were fed the AIN-76A diet (which contains 50% of the calories in the form of sucrose) or an isocaloric diet in which the sucrose was replaced by meat or fish, for 5 or 9 weeks, Manifestation of mutants requires similar to1 week in this system, so this corresponds to an effective exposure of 4 and 8 weeks, respectively, There was no significant difference in the weights of animals on the different diets, and no difference in mutant frequency. Several food mutagens were present, but at low levels. These results, when considered in the light of tests of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine and amino(alpha )carboline at much higher doses (Zhang,X,-B, Tao,K.S,, Urlando,C., Shaver-Walker,P, and Heddle,J,A, (1996) Mutagenesis, 11, 43-48), indicate that there is no highly mutagenic compound missed by previous testing with bacterial assays and that mixtures of heterocyclic amines at low levels do not show great synergy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 06:22:15