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Titolo:
beta-Cell differentiation from a human pancreatic cell line in vitro and in vivo
Autore:
de la Tour, DD; Halvorsen, T; Demeterco, C; Tyrberg, B; Itkin-Ansari, P; Loy, M; Yoo, SJ; Hao, EG; Bossie, S; Levine, F;
Indirizzi:
Univ Calif San Diego, Ctr Canc, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 r Canc, La Jolla, CA 92093 USA
Titolo Testata:
MOLECULAR ENDOCRINOLOGY
fascicolo: 3, volume: 15, anno: 2001,
pagine: 476 - 483
SICI:
0888-8809(200103)15:3<476:BDFAHP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCAGON-LIKE PEPTIDE-1; HUMAN FETAL PANCREAS; INSULIN-SECRETING CELLS; GENE PROMOTER; HUMAN ISLETS; AR42J CELLS; ACTIVIN-A; IN-VITRO; GROWTH; TRANSPLANTATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Levine, F Univ Calif San Diego, Sch Med, Ctr Mol Genet, La Jolla, CA 92093USA Univ Calif San Diego La Jolla CA USA 92093 Jolla, CA 92093 USA
Citazione:
D.D. de la Tour et al., "beta-Cell differentiation from a human pancreatic cell line in vitro and in vivo", MOL ENDOCR, 15(3), 2001, pp. 476-483

Abstract

Cell transplantation therapy for diabetes is limited by an inadequate supply of cells exhibiting glucose-responsive insulin secretion. To generate anunlimited supply of human beta -cells, inducibly transformed pancreatic beta -cell lines have been created by expression of dominant oncogenes. The cell lines grow indefinitely but lose differentiated function. Induction of beta -cell differentiation was achieved by stimulating the signaling pathways downstream of the transcription factor PDX-1, cell-cell contact, and theglucagon-like peptide (GLP-1) receptor. Synergistic activation of those pathways resulted in differentiation into functional beta -cells exhibiting glucose-responsive insulin secretion in vitro. Both oncogene-expressing and oncogene-deleted cells were transplanted into nude mice and found to exhibit glucose-responsive insulin secretion in vivo. The ability to grow unlimited quantities of human beta -cells is a major step toward developing a celltransplantation therapy for diabetes.

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Documento generato il 07/07/20 alle ore 19:05:52