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Titolo:
Peripheral T-cell lymphoma with aberrant expression of CD79a and CD20: A diagnostic pitfall
Autore:
Yao, X; Teruya-Feldstein, J; Raffeld, M; Sorbara, L; Jaffe, ES;
Indirizzi:
NCI, Hematopathol Sect, Pathol Lab, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 pathol Sect, Pathol Lab, Bethesda, MD 20892 USA
Titolo Testata:
MODERN PATHOLOGY
fascicolo: 2, volume: 14, anno: 2001,
pagine: 105 - 110
SICI:
0893-3952(200102)14:2<105:PTLWAE>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS; HODGKINS-DISEASE; B-CELLS; SUBSET; MARKER; MB-1; NEOPLASMS; DISORDER; ENTITY;
Keywords:
CD20; CD79a; cytotoxic T-cells; immunophenotyping; monoclonal antibodies; S-100 protein; T-cell lymphoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Jaffe, ES Bldg 10,Room 2N202,10 Ctr Dr MSC-1500, Bethesda, MD 20892 USA Bldg 10,Room 2N202,10 Ctr Dr MSC-1500 Bethesda MD USA 20892 USA
Citazione:
X. Yao et al., "Peripheral T-cell lymphoma with aberrant expression of CD79a and CD20: A diagnostic pitfall", MOD PATHOL, 14(2), 2001, pp. 105-110

Abstract

Immunohistochemical studies are increasingly used for the routine diagnosis of lymphomas as it is widely accepted that lymphomas of different cell lineages vary in their prognosis and response to therapy. A case of peripheral T-cell lymphoma with aberrant expression of B-cell-associated antigens L-26 (CD20) and mb-1 (CD 79a) is described. The disease pursued al aggressiveclinical course, and the patient died of disease 6 weeks after presentation. Immunohistochemical studies demonstrated expression of both T- and B-cell-associated antigens, including CD3, CD8, CD43, TIA-1, CD20, and CD79a. Other markers expressed by the tumor cells included CD56 and S-100. Of interest, betaF-1 staining for the beta chain of T-cell receptor (TCR) complex was positive in the small admired T lymphocytes but was negative in the tumor cells, raising the possibility of a gamma/delta T-cell lymphoma Molecular studies by polymerase chain reaction (PCR) demonstrated clonal TCR-gamma chain gene rearrangement without evidence for a clonal rearrangement of the immunoglobulin heavy chain gene. PCR for HHV-8 related sequences was negative. Mh-1 is an IgM-associated protein that was thought to be restricted to normal and neoplastic B cells. Although its coexpression has been reported in up to 10% cases of precursor T-cell lymphoblastic lymphoma the coexpressionof both CD20 and CD79a has not been described in mature T-cell malignancies. Biphenotypic lymphomas associated with HHV-8 have been reported in immunodeficiency, but no evidence of immune deficiency was identified, and studies for EBV and HHV-8 were negative. This case illustrates that no marker has absolute lineage specificity and that immunophenotypic studies should always be performed with panels of monoclonal antibodies. Moreover, cases withambiguous phenotypes may require genotypic studies for precise lineage assignment.

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Documento generato il 02/04/20 alle ore 19:27:10