Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Deregulated expression of cell cycle-associated proteins in solid pseudopapillary tumor of the pancreas
Autore:
Muller-Hocker, J; Zietz, C; Sendelhofert, A;
Indirizzi:
Univ Munich, Inst Pathol, D-80337 Munich, Germany Univ Munich Munich Germany D-80337 Inst Pathol, D-80337 Munich, Germany
Titolo Testata:
MODERN PATHOLOGY
fascicolo: 2, volume: 14, anno: 2001,
pagine: 47 - 53
SICI:
0893-3952(200102)14:2<47:DEOCCP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAPILLARY CYSTIC TUMOR; IMMUNOHISTOCHEMICAL EVALUATION; HER-2/NEU EXPRESSION; P27(KIP1) EXPRESSION; DEPENDENT KINASES; HUMAN CANCER; D1 GENE; K-RAS; CARCINOMAS; P53;
Keywords:
cell cycle proteins; immunohistochemistry; pancreas; solid pseudopapillary tumor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Muller-Hocker, J Univ Munich, Inst Pathol, Thalkirchner Str 36, D-80337 Munich, Germany Univ Munich Thalkirchner Str 36 Munich Germany D-80337 y
Citazione:
J. Muller-Hocker et al., "Deregulated expression of cell cycle-associated proteins in solid pseudopapillary tumor of the pancreas", MOD PATHOL, 14(2), 2001, pp. 47-53

Abstract

Solid pseudopapillary tumor of the pancreas was studied in a 20-year-old woman and a 54-year-old woman. In the younger patient, the tumor had metastasized to the liver 8 years after distal pancreatectomy, In both neoplasms, the distinct histologic pattern of solid, pseudopapillary, and degenerativecystic areas was present. Analysis by means of immunohistochemistry revealed a diffuse expression for vimentin, neuron-specific enolase, and a focal positivity for alpha1-antitrypsin, whereas epithelial markers were negativein the tumor of the older patient and only focally expressed in the tumor of the younger patient. Immunohistochemical analysis of cell cycle-associated proteins provided an overexpression of cyclin D1 and cyclin D3 in both tumors, although to varying degrees. In addition, the cyclin-dependent kinase inhibitors p21, and to a lesser extent p27, were up-regulated just as mdm2. There was no accumulation of p53 protein, and Ki67-positive cells were extremely scarce. Analysis of the liver metastases showed an immunoreactive profile similar to that of the primary tumor. The results show a deregulation of the cell cycle with overexpression of cell cycle activating proteins D1 and D3 and a probably counterbalancing upregulation of the cyclin-dependent kinase inhibitors p21 and p27, The findings may explain the low pool ofKi67-reactive tumor cells and the generally good clinical outcome of thesetumors. Whether a more profound dysbalance of the cell cycle regulation isresponsible for the development of metastatic disease remains to be clarified.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 03:49:07