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Titolo:
Pancreatic enzymes and microvascular cell activation in multiorgan failure
Autore:
Schmid-Schonbein, GW; Hugli, TE; Kistler, EB; Sofianos, A; Mitsuoka, H;
Indirizzi:
Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 ioengn, La Jolla, CA 92093 USA Scripps Clin & Res Fdn, Res Inst, Dept Immunol, La Jolla, CA 92037 USA Scripps Clin & Res Fdn La Jolla CA USA 92037 unol, La Jolla, CA 92037 USA
Titolo Testata:
MICROCIRCULATION
fascicolo: 1, volume: 8, anno: 2001,
pagine: 5 - 14
SICI:
1073-9688(200102)8:1<5:PEAMCA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTESTINAL ISCHEMIA-REPERFUSION; SPONTANEOUSLY HYPERTENSIVE RATS; HEMORRHAGIC-SHOCK; IN-VIVO; SKELETAL-MUSCLE; NEUTROPHIL ACTIVATION; LEUKOCYTE ACTIVATION; ENDOTHELIAL-CELLS; NITRIC-OXIDE; OXIDATIVE STRESS;
Keywords:
endothelium; flee radicals; neutrophil; protease; pseudopod formation; shock;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
96
Recensione:
Indirizzi per estratti:
Indirizzo: Schmid-Schonbein, GW Univ Calif San Diego, Dept Biomed Engn, 9500 Gilman Dr,0412, La Jolla, CA 92093 USA Univ Calif San Diego 9500 Gilman Dr,0412 La Jolla CA USA 92093
Citazione:
G.W. Schmid-Schonbein et al., "Pancreatic enzymes and microvascular cell activation in multiorgan failure", MICROCIRCUL, 8(1), 2001, pp. 5-14

Abstract

Cell activation in the microcirculation leads to an inflammatory cascade and is accompanied by many cardiovascular complications. There is a need to identify the trigger mechanisms that lead to the production of in vivo activating factors. We review here mechanisms for cell activation in the microcirculation and specifically the production of humoral cell activators in physiological shock. The elevated levels of activating factors in plasma could be traced to the action of pancreatic enzymes in the ischemic intestine. New interventions against the production of the activators are proposed. The evidence suggests that pancreatic enzymes in the ischemic intestine may attack several tissue components and generate cellular activators that are associated with multiorgan dysfunction in physiological shock.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:35:39