Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
COS-I, a putative two-component histidine kinase of Candida albicans, is an in vivo virulence factor
Autore:
Selitrennikoff, CP; Alex, L; Miller, TK; Clemons, KV; Simon, MI; Stevens, DA;
Indirizzi:
Univ Colorado, Hlth Sci Ctr, Dept Cellular & Struct Biol, Denver, CO 80262USA Univ Colorado Denver CO USA 80262 ular & Struct Biol, Denver, CO 80262USA CALTECH, Div Biol, Pasadena, CA 91125 USA CALTECH Pasadena CA USA 91125CALTECH, Div Biol, Pasadena, CA 91125 USA Santa Clara Valley Med Ctr, Dept Med, Div Infect Dis, San Jose, CA 95128 USA Santa Clara Valley Med Ctr San Jose CA USA 95128 , San Jose, CA 95128 USA
Titolo Testata:
MEDICAL MYCOLOGY
fascicolo: 1, volume: 39, anno: 2001,
pagine: 69 - 74
SICI:
1369-3786(200102)39:1<69:CAPTHK>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL-TRANSDUCTION SYSTEMS; HYPHAL DEVELOPMENT; PROTEIN-KINASE; INTERMOLECULAR COMPLEMENTATION; NEUROSPORA-CRASSA; AMPHOTERICIN-B; MURINE MODEL; YEAST; MAP; GENE;
Keywords:
Candida albicans; COS-1; in vivo virulence; two-component histidine kinases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Selitrennikoff, CP Univ Colorado, Hlth Sci Ctr, Dept Cellular & Struct Biol, 4200 E 9th Ave,B-111, Denver, CO 80262 USA Univ Colorado 4200 E 9th Ave,B-111 Denver CO USA 80262
Citazione:
C.P. Selitrennikoff et al., "COS-I, a putative two-component histidine kinase of Candida albicans, is an in vivo virulence factor", MED MYCOL, 39(1), 2001, pp. 69-74

Abstract

The human fungal pathogen, Candida albicans, has three putative histidine kinases showing homology to those of plants, bacteria and other fungi. We have constructed a homozygous deletion strain and a hemizygous reconstitutedstrain of one of these histidine-kinase-encoding genes, COS-1, in C. albicans. Neither strain showed any growth defect in a number of liquid media nor increased resistance or sensitivity to a number of antifungal drugs, Importantly, we show that the COS-1 homozygous disruption strain had significantly reduced virulence in a systemic murine model of candidosis. Thus, COS-1appears to be an in vivo virulence factor and may represent a novel targetfor the development of antifungal drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:01:29