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Titolo:
Role of chemokines in fungal infections
Autore:
Traynor, TR; Huffnagle, GB;
Indirizzi:
Univ Michigan, Med Ctr, Div Pulm, Sch Med,Dept Internal Med, Ann Arbor, MI48109 USA Univ Michigan Ann Arbor MI USA 48109 Internal Med, Ann Arbor, MI48109 USA Univ Michigan, Sch Med, Dept Immunol Microbiol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 l Microbiol, Ann Arbor, MI 48109 USA
Titolo Testata:
MEDICAL MYCOLOGY
fascicolo: 1, volume: 39, anno: 2001,
pagine: 41 - 50
SICI:
1369-3786(200102)39:1<41:ROCIFI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CRYPTOCOCCUS-NEOFORMANS INFECTION; MONOCYTE CHEMOATTRACTANT PROTEIN-1; PNEUMOCYSTIS-CARINII PNEUMONIA; ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS; MACROPHAGE INFLAMMATORY PROTEIN-1-ALPHA; MAJOR SURFACE GLYCOPROTEIN; EPITHELIAL-CELL LINES; NECROSIS-FACTOR-ALPHA; C-C CHEMOKINE; CD8+ T-CELLS;
Keywords:
chemokine; chemotaxis; fungi; leukocyte;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Huffnagle, GB Univ Michigan, Med Ctr, Div Pulm, Sch Med,Dept Internal Med,6301 MSRB IIIBox 0642, Ann Arbor, MI 48109 USA Univ Michigan 6301 MSRB IIIBox 0642 Ann Arbor MI USA 48109
Citazione:
T.R. Traynor e G.B. Huffnagle, "Role of chemokines in fungal infections", MED MYCOL, 39(1), 2001, pp. 41-50

Abstract

The production of chemokines at the site of a fungal infection is criticalfor effective recruitment of leukocytes to that site. Over 40 chemokines and 20 chemokine receptors have been identified. The most intriguing biological property of chemokines is that they often play non-redundant roles in vivo even though they are highly related, have multiple activities and bind multiple chemokine receptors, Almost all of the chemokine studies to date have concentrated on responses to Cryptococcus, Candida, Aspergillus or Pneumocystic. The role of chemokines in infections caused by fungi such as Histoplasma, Blastomyces, Coccidioides and Paracoccidioides remains to be explored. In this review we have summarized what is currently known about the role of chemokines during fungal infection, including the influence of these signaling proteins on effector cell recruitment and development of cell-mediated immunity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:23:21