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Titolo:
Fine mapping of Hyplip1 and the human homolog, a potential locus for FCHL
Autore:
Pajukanta, P; Bodnar, JS; Sallinen, R; Chu, M; Airaksinen, T; Xiao, QN; Castellani, LW; Sheth, SS; Wessman, M; Palotie, A; Sinsheimer, JS; Demant, P; Lusis, AJ; Peltonen, L;
Indirizzi:
Univ Calif Los Angeles, Dept Human Genet, Gonda Neurosci & Genet Res Ctr, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA Univ Calif LosAngeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Dept Microbiol & Mol Genet, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Helsinki, Cent Hosp, Dept Clin Chem, FIN-00014 Helsinki, Finland UnivHelsinki Helsinki Finland FIN-00014 em, FIN-00014 Helsinki, Finland Univ Helsinki, Div Genet, Dept Biosci, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 ci, FIN-00014 Helsinki, Finland Univ Calif Los Angeles, Dept Biomath, Los Angeles, CA 90024 USA Univ CalifLos Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Netherlands Canc Inst, Div Mol Genet, NL-1066 CX Amsterdam, Netherlands Netherlands Canc Inst Amsterdam Netherlands NL-1066 CX rdam, Netherlands
Titolo Testata:
MAMMALIAN GENOME
fascicolo: 3, volume: 12, anno: 2001,
pagine: 238 - 245
SICI:
0938-8990(200103)12:3<238:FMOHAT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL COMBINED HYPERLIPIDEMIA; CORONARY-ARTERY DISEASE; AIV GENE-CLUSTER; CHROMOSOME 1Q21-Q23; FINNISH FAMILIES; COMPLEX TRAITS; HEART-DISEASE; LINKAGE; HYBRIDIZATION; CHOLESTEROL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Peltonen, L Univ Calif Los Angeles, Dept Human Genet, Gonda Neurosci & Genet Res Ctr, 695 Charles E Young Dr S,Box 708822, Los Angeles, CA 90095 USA Univ Calif Los Angeles 695 Charles E Young Dr S,Box 708822 Los Angeles CA USA 90095
Citazione:
P. Pajukanta et al., "Fine mapping of Hyplip1 and the human homolog, a potential locus for FCHL", MAMM GENOME, 12(3), 2001, pp. 238-245

Abstract

Familial combined hyperlipidemia (FCHL) is a common genetic dyslipidemia predisposing to premature coronary heart disease (CHD). We previously identified a locus for FCHL on human Chromosome (Chr) 1q21-q23 in 31 Finnish FCHLfamilies. We also mapped a gene for combined hyperlipidemia (Hyplip1) to apotentially orthologous region of mouse Chr 3 in the HcB-19/Dem mouse model of FCHL. The human FCHL locus was, however, originally mapped about 5 Mb telomeric to the synteny border, the centromeric part of which is homologous to mouse Chr 3 and the telomeric part to mouse Chr 1. To further localizethe human Hyplip1 homolog and estimate its distance from the peak linkage markers. we fine-mapped the Hyplip1 locus and defined the borders of the region of conserved synteny be tween human and mouse. This involved establishing a physical map of a bacterial artificial chromosome (BAC) contig acrossthe Hyplip1 locus and hybridizing a set of BACs to both human and mouse chromosomes by fluorescence in situ hybridization (FISH). We narrowed the location of the mouse Hyplip1 gene to a 1.5-cM region that is homologous only with human 1q21 and within approximately 5-10 Mb of the peak marker for linkage to FCHL. FCHL is a complex disorder and this distance may, thus, reflect the well-known problems hampering the mapping of complex disorders. Further studies identifying and sequencing the Hyplip1 gene will show whether the same gene predisposes to hyperlipidemia in human and mouse.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:17:32