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Titolo:
Effects of caloric restriction on skeletal muscle mitochondrial proton leak in aging rats
Autore:
Lal, SB; Ramsey, JJ; Monemdjou, S; Weindruch, R; Harper, ME;
Indirizzi:
Univ Ottawa, Fac Med, Dept Biochem Microbiol & Immunol, Ottawa, ON K1H 8M5, Canada Univ Ottawa Ottawa ON Canada K1H 8M5 Immunol, Ottawa, ON K1H 8M5, Canada Univ Wisconsin, Wisconsin Reg Primate Res Ctr, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 rimate Res Ctr, Madison, WI 53706 USA Univ Wisconsin, Dept Med, Madison, WI 53706 USA Univ Wisconsin Madison WIUSA 53706 nsin, Dept Med, Madison, WI 53706 USA Vet Adm Geriatr Res Educ & Clin Ctr, Madison, WI USA Vet Adm Geriatr Res Educ & Clin Ctr Madison WI USA Ctr, Madison, WI USA
Titolo Testata:
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
fascicolo: 3, volume: 56, anno: 2001,
pagine: B116 - B122
SICI:
1079-5006(200103)56:3<B116:EOCROS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNCOUPLING PROTEIN HOMOLOG; LIVER-MITOCHONDRIA; FOOD RESTRICTION; OXIDATIVE DAMAGE; INNER MEMBRANE; ATP TURNOVER; HEPATOCYTES; STRESS; AGE; PERMEABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Harper, ME Univ Ottawa, Fac Med, Dept Biochem Microbiol & Immunol, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada Univ Ottawa 451 Smyth Rd Ottawa ON CanadaK1H 8M5 H 8M5, Canada
Citazione:
S.B. Lal et al., "Effects of caloric restriction on skeletal muscle mitochondrial proton leak in aging rats", J GERONT A, 56(3), 2001, pp. B116-B122

Abstract

Long-term caloric restriction (CR) retards aging processes and increases maximum life span. We investigated the influence of CR on mitochondrial proton leaks in rat skeletal muscle. Because CR lowers oxidative damage to mitochondrial membrane lipids and proteins, we hypothesized that leak would be lower in mitochondria from old CR rats than in age-matched controls. Three groups (n = 12) were studied: 4-month-old "young" control rats (body weight: 404 g +/- 7 SEM), 33-month-old CR rats (body weight: 262 g +/- 3), and 33-month-old control rats (body weight: 446 g +/- 5). CR rats received 67% ofthe energy intake of old control rats, with adequate intakes of all essential nutrients. Maximum leak-dependent O-2 consumption (State 3) was 23% lower in CR rats than in age-matched controls, whereas protonmotive force values were similar, supporting our hypothesis. The overall kinetics of leak were similar between the two groups of old rats; in the young, kinetics indicated higher protonmotive force values. The latter indication is consistent with aging-induced alterations in proton leak kinetics that are independentof dietary intervention. There was no influence of age or diet on serum T-4 level, whereas T-3 was lower in young than in old control rats. These results support and extend the oxidative stress hypothesis of aging.

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Documento generato il 30/09/20 alle ore 03:59:52