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Titolo:
Maternal serum leptin concentrations do not correlate with cord blood leptin concentrations in normal pregnancy
Autore:
Laml, T; Hartmann, BW; Ruecklinger, E; Preyer, O; Soeregi, G; Wagenbichler, P;
Indirizzi:
Univ Vienna, Sch Med, Dept Obstet & Gynecol, Div Gynecol,Div Special Gynecol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 pecial Gynecol, A-1090 Vienna, Austria Inst Stat Anal, Vienna, Austria Inst Stat Anal Vienna AustriaInst Stat Anal, Vienna, Austria Univ Vienna, Sch Med, Inst Med, Vienna, Austria Univ Vienna Vienna Austria v Vienna, Sch Med, Inst Med, Vienna, Austria Chem Labs, Vienna, Austria Chem Labs Vienna AustriaChem Labs, Vienna, Austria Ignaz Semmelweis Fauenklin Stadt Wien, Vienna, Austria Ignaz Semmelweis Fauenklin Stadt Wien Vienna Austria n, Vienna, Austria
Titolo Testata:
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
fascicolo: 1, volume: 8, anno: 2001,
pagine: 43 - 47
SICI:
1071-5576(200101/02)8:1<43:MSLCDN>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-COMPOSITION; PLASMA LEPTIN; FETAL GROWTH; OBESE GENE; INTRAUTERINE GROWTH; PRETERM DELIVERY; PLACENTAL WEIGHT; AMNIOTIC-FLUID; FAT MASS; GENDER;
Keywords:
maternal leptin; cord blood leptin; pregnancy; anthropometric measurements;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Laml, T Univ Vienna, Sch Med, Dept Obstet & Gynecol, Div Gynecol,Div Special Gynecol, Waehringer Guertel 18-20, A-1090 Vienna, Austria Univ Vienna Waehringer Guertel 18-20 Vienna Austria A-1090 ustria
Citazione:
T. Laml et al., "Maternal serum leptin concentrations do not correlate with cord blood leptin concentrations in normal pregnancy", J SOC GYN I, 8(1), 2001, pp. 43-47

Abstract

OBJECTIVE: To determine whether there is a difference in maternal leptin concentration and cord blood concentration, consistent with the hypothesis of a noncommunicating, two-compartement model of fetoplacental leptin regulation. METHODS: Blood samples were collected from 139 women, identified as havingan uncomplicated pregnancy, from an antecubital vein at delivery. Cord blood samples were taken from the umbilical vein. Leptin was measured by radioimmunoassay, and its relationship to fetal and maternal anthropometrics wasassessed by Spearman correlation. Differences in maternal and cord blood leptin levels between male and female infants were tested with the Mann-Whitney U tests. Maternal and cord blood leptin were compared by the Wilcoxon signed rank test. The outcome measures were maternal and cord blood leptin at delivery, fetal birth weight, length, weight/length ratio, and ponderal index, maternal prepregnancy body mass index, pregnancy weight gain, relative weight gain, and body mass index at delivery. RESULTS: No correlations were found between maternal and cord blood leptinconcentrations. Fetal leptin level correlated with birth weight (rho = 0.665; P < .0001), length (<rho> = 0. 490; P < .0001), ponderal index (<rho> =0.260. P = .002), and weight/length ratio (rho = 0.625; P < .0001). Medianleptin concentrations were higher in female (9.3 ng/mL, range 1.5-34.4 ng/mL) than in male (8.2 ng/mL, range 1.6-38.3 ng/mL) neonates, but this difference was statistically not significant. Logistic regression analysis showed a significant influence on umbilical venous leptin concentration for birth weight (P < .0001) but not for gender. Maternal leptin concentrations were significantly higher than cord leptin concentrations (P < .0005 for the male and female neonates and the entire group). CONCLUSION: Their tvas no correlation between maternal and cord leptin, which supports the hypothesis of a noncommunicating, two-compartment model offetoplacental leptin regulation. Copyright (C) 2001 by the Society for Gynecologic Investigation.

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Documento generato il 18/01/20 alle ore 07:26:08