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Titolo:
Maternal basic fibroblast growth factor serum levels are associated with pregnancy-induced hypertension
Autore:
Kurz, C; Hefler, L; Zeisler, H; Schatten, C; Husslein, P; Tempfer, C;
Indirizzi:
Univ Vienna, Sch Med, Dept Gynecol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 , Dept Gynecol, A-1090 Vienna, Austria Univ Vienna, Sch Med, Dept Obstet & Gynecol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 stet & Gynecol, A-1090 Vienna, Austria Baylor Coll Med, Dept Obstet & Gynecol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 tet & Gynecol, Houston, TX 77030 USA
Titolo Testata:
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
fascicolo: 1, volume: 8, anno: 2001,
pagine: 24 - 26
SICI:
1071-5576(200101/02)8:1<24:MBFGFS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-II; EXPRESSION; UTERINE; CELLS;
Keywords:
bFGF; pregnancy-induced hypertension; serum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Tempfer, C Univ Vienna, Sch Med, Dept Obstet, Wahringer Gurtel 18-20, A-1090 Vienna, Austria Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090 stria
Citazione:
C. Kurz et al., "Maternal basic fibroblast growth factor serum levels are associated with pregnancy-induced hypertension", J SOC GYN I, 8(1), 2001, pp. 24-26

Abstract

OBJECTIVE: To test the hypothesis that serum levels of basic fibroblast growth factor (bFGF) are altered among women with pregnancy-induced hypertension (PIH) and are associated with disease severity. METHODS: We evaluated serum levels of bFGF in 46 women with PIH, 46 age- and parity-matched healthy pregnant women, and 46 healthy nonpregnant controls. Enzyme-linked immunosorbent assays were used to determine serum levels of bFGF. Results were correlated to clinical data. RESULTS: The overall mean serum levels of bFGF were 3.2 (standard deviation [SD] 9.3) mu mol/L. Mean serum levels of bFGF in normal controls, healthypregnant women, and women with PIH were 0 (SD 0) mu mol/L, 2.6 (SD 6.3) mumol/L, and 6.8 (SD 13.8) mu mol/L, respectively (P = .003) for normal controls compared with healthy pregnant women and P < .001 for healthy pregnantwomen compared with women with PIH). In a univariate logistic regression model bFGF showed a significant influence on the odds of presenting with PIHcompared with healthy pregnant women (P = .002). The mean serum levels of bFGF in women with severe PIH and in women with mild PIH were 4.4 (SD 10.6)<mu>mol/L and 9.5 (SD 17.3) mu mol/L, respectively (P = .1). In a univariate logistic regression model bFGF did not reveal a significant influence onthe odds of developing severe PIH (P = .3). CONCLUSIONS: Elevated serum levels of bFGF are associated with PIH, but bFGF does not seem to be a useful prognostic parameter for sever PIH. Copyright (C) 2001 by the Society for Gynecologic Investigation.

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Documento generato il 10/07/20 alle ore 03:10:39