Catalogo Articoli (Spogli Riviste)

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Titolo:
Repeat liver resection for hepatocellular carcinoma
Autore:
Nakajima, Y; Ko, S; Kanamura, T; Nagao, M; Kanehiro, H; Hisanaga, M; Aomatsu, Y; Ikeda, N; Nakano, H;
Indirizzi:
Nara Med Univ, Dept Surg 1, Nara 6340813, Japan Nara Med Univ Nara Japan6340813 Univ, Dept Surg 1, Nara 6340813, Japan
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
fascicolo: 3, volume: 192, anno: 2001,
pagine: 339 - 344
SICI:
1072-7515(200103)192:3<339:RLRFHC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC RESECTION; HEPATECTOMY; RECURRENCE; PROGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Nakajima, Y Nara Med Univ, Dept Surg 1, 840 Shijo Cho, Nara 6340813, JapanNara Med Univ 840 Shijo Cho Nara Japan 6340813 6340813, Japan
Citazione:
Y. Nakajima et al., "Repeat liver resection for hepatocellular carcinoma", J AM COLL S, 192(3), 2001, pp. 339-344

Abstract

BACKGROUND: Although hepatectomy has been accepted as a therapeutic optionfor the primary tumor of hepatocellular carcinoma (HCC), what role the second liver resection will play in the clinical care of patients with intrahepatic recurrence of HCC after the initial resection has not been well evaluated. STUDY DESIGN: In a retrospective review of the 6-year period between January 1991 and December 1996, records were examined of 94 patients who underwent curative liver resection for HCC. Of these, 57 patients had isolated recurrent disease to the liver; 12 of the 57 patients underwent repeat surgical resection and 45 patients received nonsurgical ablative therapy. Clinicaldata for these patients were reviewed for operative morbidity and mortality, survival, disease-free survival, and pattern of failure. RESULTS: There were no perioperative deaths during repeat liver resectionsfor recurrent HCC. Operative morbidity in the second resection was comparable to the initial resection. The disease-free survival rate after the second hepatectomy was 31% at 2 years, significantly lower than that after initial hepatectomy (62%) (p = 0.009). The overall survival rate after the second hepatectomy was 90% at 2 years, in contrast to 70% after nonsurgical ablative treatment for recurrent HCC (p = 0.253). CONCLUSIONS: Although the second liver resection for recurrent HCC can be performed safely and may improve survival, the disease-free survival rate after such resection therapy is low This likelihood of further recurrences encourages studies for the selection of patients who may benefit from repeatliver resection. (J Am Coll Surg 2001;192:339-344. (C) 2001 by the American College of Surgeons).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 12:20:40