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Titolo:
Interleukin-6 production in lung tissue after transthoracic esophagectomy
Autore:
Abe, T; Oka, M; Tangoku, A; Hayashi, H; Yamamoto, K; Yahara, N; Morita, K; Tabata, T; Ohmoto, Y;
Indirizzi:
Yamaguchi Univ, Sch Med, Dept Surg 2, Yamaguchi 7558505, Japan Yamaguchi Univ Yamaguchi Japan 7558505 Surg 2, Yamaguchi 7558505, Japan Otsuka Cellular Technol Inst, Tokushima, Japan Otsuka Cellular Technol Inst Tokushima Japan nol Inst, Tokushima, Japan
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
fascicolo: 3, volume: 192, anno: 2001,
pagine: 322 - 329
SICI:
1072-7515(200103)192:3<322:IPILTA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHIAL EPITHELIAL-CELLS; COLONY-STIMULATING FACTOR; TUMOR-NECROSIS-FACTOR; INFLAMMATORY CYTOKINES; GROWTH-FACTOR; SERUM INTERLEUKIN-6; ABDOMINAL-SURGERY; ELECTIVE SURGERY; PERITONEAL-FLUID; IL-6;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Oka, M Yamaguchi Univ, Sch Med, Dept Surg 2, 1-1-1 Minamikogushi, Yamaguchi 7558505, Japan Yamaguchi Univ 1-1-1 Minamikogushi Yamaguchi Japan 7558505 , Japan
Citazione:
T. Abe et al., "Interleukin-6 production in lung tissue after transthoracic esophagectomy", J AM COLL S, 192(3), 2001, pp. 322-329

Abstract

BACKGROUND: The mechanisms of the reported high increase in interleukin-6 (IL-6) levels after esophagectomy are unclear. We investigated the influence of an intrathoracic procedure, esophagectomy, on IL-6 production in lung tissue. STUDY DESIGN: Fourteen paired lung tissue samples were obtained from patients before and after they underwent transthoracic esophagectomy for esophageal cancer. IL-6 levels in the lung were measured with enzyme-linked immunosorbent assay, and IL-6 mRNA expression was determined with real-time quantitative reverse transcription-polymerase chain reaction. Immunohistochemical staining was used to localize IL-6, and circulating levels were also measured. RESULTS: IL-6 protein and mRNA were significantly increased in lung tissueafter this intrathoracic procedure (p < 0.05). Peak levels of plasma IL-6 after surgery were correlated with IL-6 levels in lung tissues obtained after the procedure (p < 0.05). Immunohistochemical staining revealed IL-6 production from alveolar and bronchial epithelial cells but not from alveolar macrophages. CONCLUSIONS: Transthoracic esophagectomy causes an increase in IL-6 production from airway epithelial cells, secondary to increased expression of IL-6 mRNA. Local response of lung tissue may be one source of increased serum IL-6 after this procedure. (J Am Coll Surg 2001;192:322-329. (C) 2001 by the American College of Surgeons).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 11:14:14