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Titolo:
XANES spectroscopy of a single neuron from a patient with Parkinson's disease
Autore:
Yoshida, S; Ektessabi, A; Fujisawa, S;
Indirizzi:
Wakayama Med Coll, Dept Neurol, Wakayama 6418511, Japan Wakayama Med CollWakayama Japan 6418511 Neurol, Wakayama 6418511, Japan Kyoto Univ, Grad Sch Engn, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 Univ, Grad Sch Engn, Kyoto 6068501, Japan
Titolo Testata:
JOURNAL OF SYNCHROTRON RADIATION
, volume: 8, anno: 2001,
parte:, 2
pagine: 998 - 1000
SICI:
0909-0495(200103)8:<998:XSOASN>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
X-RAY-MICROANALYSIS; SYNCHROTRON-RADIATION; SUBSTANTIA-NIGRA; IRON; BRAINS; NEUROMELANIN; MICROPROBE; INCREASE;
Keywords:
neuron; neuromelanin; chemical state; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Yoshida, S Wakayama Med Coll, Dept Neurol, Wakayama 6418511, Japan Wakayama Med Coll Wakayama Japan 6418511 ayama 6418511, Japan
Citazione:
S. Yoshida et al., "XANES spectroscopy of a single neuron from a patient with Parkinson's disease", J SYNCHROTR, 8, 2001, pp. 998-1000

Abstract

Chemical state of transition metals such as iron in a single neuron of thesubstantia nigra (SN) from a patient with Parkinson's disease (PD) was studied in this paper, using autopsy midbrain specimens including SN. Parkinson's disease is one of the major neurodegenerative diseases. The excessive accumulation of iron and its chemical states in SN neurons are related to the oxidative damage leading to neuronal cell death. X-ray absorption fine structure spectroscopy (XAFS) with SR micro beam (10 mum) was used to investigate the chemical state of iron in the SN neurons. X-ray absorption near-edge structure (XANES) spectroscopy results showed that the chemical state ofiron in the neuromelanin granules within SN neurons changed from ferrous (Fe2+) to ferric (Fe3+) ion in the process of neuronal degeneration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:36:46