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Titolo:
Lipodystrophy in patients with juvenile dermatomyositis - Evaluation of clinical and metabolic abnormalities
Autore:
Huemer, C; Kitson, H; Malleson, PN; Sanderson, S; Huemer, M; Cabral, DA; Chanoine, JP; Petty, RE;
Indirizzi:
Univ Vienna, Dept Pediat, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 a, Dept Pediat, A-1090 Vienna, Austria Univ British Columbia, Dept Pediat, Div Rheumatol, Vancouver, BC V6T 1W5, Canada Univ British Columbia Vancouver BC Canada V6T 1W5 ver, BC V6T 1W5, Canada Univ British Columbia, Dept Pediat, Div Endocrinol, Vancouver, BC V6T 1W5,Canada Univ British Columbia Vancouver BC Canada V6T 1W5 uver, BC V6T 1W5,Canada
Titolo Testata:
JOURNAL OF RHEUMATOLOGY
fascicolo: 3, volume: 28, anno: 2001,
pagine: 610 - 615
SICI:
0315-162X(200103)28:3<610:LIPWJD>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACYLATION STIMULATING PROTEIN; INSULIN-RESISTANCE; GLUCOSE; SENSITIVITY; LIPOATROPHY; MECHANISMS; DISEASE;
Keywords:
juvenile dermatomyositis; lipodystrophy; lipoatrophic diabetes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Huemer, C Univ Vienna, Dept Pediat, Wahringer Gurtel 18-20, A-1090 Vienna,Austria Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090 ustria
Citazione:
C. Huemer et al., "Lipodystrophy in patients with juvenile dermatomyositis - Evaluation of clinical and metabolic abnormalities", J RHEUMATOL, 28(3), 2001, pp. 610-615

Abstract

Objective. Lipodystrophy and associated metabolic abnormalities are being increasingly recognized as complications of juvenile dermatomyositis (JDM). We investigated the prevalence of lipodystrophy and the extent of metabolic abnormalities related to lipoatrophic diabetes mellitus in patients with JDM. Methods. Twenty patients with JDM were evaluated for evidence of lipodystrophy and associated lipoatrophic diabetes mellitus. All patients underwent clinical assessment, laboratory investigations, and metabolic studies (oralglucose tolerance test, lipid studies, insulin antibodies). Results, We found clinical evidence of Lipodystrophy and lipoatrophic diabetes mellitus in 4 of 20 patients with JDM and metabolic abnormalities known to be associated with lipodystrophy in another 8 patients. The 20 patients with JDM were categorized as follows: Group 1 (Patients 1-4) consisted ofpatients with lipodystrophy and either diabetes mellitus (2 patients) or impaired glucose tolerance (2 patients); Group 2 (Patients 5-12): no lipodystrophy but abnormal glucose and/or lipid studies; Group 3 (Patients 13-20):no lipodystrophy and no abnormalities of glucose and lipid studies. Conclusion, We found 25% of patients with JDM have lipodystrophy, and 50% present with hypertriglyceridemia and insulin resistance. Screening for metabolic abnormalities in JDM should be included in routine followup because of the effect of lipodystrophy on longterm prognosis.

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Documento generato il 11/07/20 alle ore 17:41:28