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Titolo:
Relationship between parity and clinical and biological features in patients with systemic sclerosis
Autore:
Launay, D; Hebbar, M; Hatron, PY; Michon-Pasturel, U; Queyrel, V; Hachulla, E; Devulder, B;
Indirizzi:
CHRU, Hop Claude Huriez, Serv Med Interne, F-59037 Lille, France CHRU Lille France F-59037 uriez, Serv Med Interne, F-59037 Lille, France
Titolo Testata:
JOURNAL OF RHEUMATOLOGY
fascicolo: 3, volume: 28, anno: 2001,
pagine: 509 - 513
SICI:
0315-162X(200103)28:3<509:RBPACA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; MATERNAL BLOOD; HOST DISEASE; AUTOIMMUNE-DISEASE; PULMONARY-FUNCTION; PERIPHERAL-BLOOD; CHRONIC GRAFT; FETAL CELLS; E-SELECTIN; SCLERODERMA;
Keywords:
systemic sclerosis; pregnancy; microchimerism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Hebbar, M CHRU, Hop Claude Huriez, Serv Med Interne, 1 Pl Verdun, F-59037 Lille, France CHRU 1 Pl Verdun Lille France F-59037 un, F-59037 Lille, France
Citazione:
D. Launay et al., "Relationship between parity and clinical and biological features in patients with systemic sclerosis", J RHEUMATOL, 28(3), 2001, pp. 509-513

Abstract

Objective. To assess the influence of parity on the clinical and biological features of systemic sclerosis (SSc). Methods. We recorded the following clinical and biological data of 100 consecutive women with SSc: age, disease duration before diagnosis, cutaneous extension of sclerosis according to LeRoy's classification, pulmonary involvement, and antinuclear antibodies. We compared these features to the number and sex of children who were born before Sc onset. Date of birth of the first children was systematically recorded. Results. Patients with limited SSc had more children before SSc onset thanpatients with diffuse SSc (2.4 +/- 1.8 vs 1.7 +/- 1.5; p < 0.05). The interval between first birth and SSc onset was shorter for patients with limited SSc than for patients with diffuse SSc (11.0 +/- 9.9 vs 23.5 +/- 14.5 yrs; p < 0.01). Patients with pulmonary fibrosis had more children than patients without pulmonary fibrosis (2.5 +/- 1.9 vs 2.0 +/- 1.6; p < 0.05). Age at first birth was significantly higher when the child was a girl than a boy(26.8 +/- 7.5 vs 22.9 +/- 5.3 yrs; p < 0.05). The interval between the first birth and SSc onset was shorter when the child was a girl than a boy (16.2 +/- 9.6 vs 25.4 +/- 13.4 yrs; p < 0.05). Conclusion. Pregnancy related microchimerism could be preferentially associated with limited SSc and pulmonary fibrosis. Microchimerism may be facilitated in cases in which the fetus is female.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 16:29:59