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Titolo:
Effect of propranolol plus exercise on melatonin and growth hormone levelsin children with growth delay
Autore:
Munoz-Hoyos, A; Hubber, E; Escames, G; Molina-Carballo, A; Macias, M; Valenzuela-Ruiz, A; Fernandez-Garcia, JM; Acuna-Castroviejo, D;
Indirizzi:
Univ Granada, Dept Pediat, E-18071 Granada, Spain Univ Granada Granada Spain E-18071 , Dept Pediat, E-18071 Granada, Spain Univ Granada, Inst Biotecnol, Dept Fisiol, E-18071 Granada, Spain Univ Granada Granada Spain E-18071 , Dept Fisiol, E-18071 Granada, Spain
Titolo Testata:
JOURNAL OF PINEAL RESEARCH
fascicolo: 2, volume: 30, anno: 2001,
pagine: 75 - 81
SICI:
0742-3098(200103)30:2<75:EOPPEO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PINEAL-GLAND; SECRETION; NALOXONE; ADENOHYPOPHYSEAL; MECHANISMS; BLOCKERS; CULTURE; HUMANS; WOMEN; LIGHT;
Keywords:
children; exercise; GH; melatonin; pineal gland; propranolol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Acuna-Castroviejo, D Fac Med, Dept Fisiol, Ave Madrid 11, E-18012 Granada,Spain Fac Med Ave Madrid 11 Granada Spain E-18012 a, Spain
Citazione:
A. Munoz-Hoyos et al., "Effect of propranolol plus exercise on melatonin and growth hormone levelsin children with growth delay", J PINEAL R, 30(2), 2001, pp. 75-81

Abstract

The pineal gland in humans is under both alpha- and beta -adrenergic control, although it seems that beta (1)-adrenoceptors are mainly implicated in melatonin secretion. In the present study, we evaluated the role of e-adrenergic innervation on melatonin production and its relation with the production of growth hormone (GH). Thirty-four children (15 males and 19 females, mean age 10.5 +/- 0.8 years) from the University of Granada Hospital were studied. The children were included in a protocol For the evaluation of growth delay using the propranolol + exercise test. This standardized test allowed us to study simultaneously the role of an unspecific beta -adrenergic blocker such as propranolol and of an adrenergic stimulus such as exercise on the pineal production of melatonin. Changes in plasma levels of melatoninand GH were determined at basal, 120 and 140 min after the test was applied. Hormonal determinations were carried out by commercial radioimmunoassay kits previously standardized in our laboratory. The results show a significant decrease in plasma melatonin levels at 120 and 140 min after the test (P < 0.05), whereas GH levels increased significantly at 140 min (P < 0.001). The decrease of melatonin levels was a consequence of the test, since in a control group. the circadian decay of melatonin was significantly less pronounced (P < 0.05). These data suggest an inverse relationship between melatonin and GH after the propranolol + exercise test, and the reduction in melatonin may be related to its depletion by exercise-induced oxidative stress.

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Documento generato il 10/07/20 alle ore 12:39:24