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Titolo:
Radiolabeled amino acids: Basic aspects and clinical applications in oncology
Autore:
Jager, PL; Vaalburg, W; Pruim, J; de Vries, EGE; Langen, KJ; Piers, DA;
Indirizzi:
Univ Groningen Hosp, Dept Nucl Med, PET Ctr, NL-9700 RB Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9700 RB ningen, Netherlands Univ Groningen Hosp, Dept Med Oncol, NL-9700 RB Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9700 RB ningen, Netherlands Res Ctr Julich, Inst Med, Julich, Germany Res Ctr Julich Julich GermanyRes Ctr Julich, Inst Med, Julich, Germany
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 3, volume: 42, anno: 2001,
pagine: 432 - 445
SICI:
0161-5505(200103)42:3<432:RAABAA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; ALPHA-METHYL-TYROSINE; PROTEIN-SYNTHESIS RATE; SQUAMOUS-CELL CARCINOMA; NON-HODGKINS-LYMPHOMA; SOFT-TISSUE TUMORS; LOW-GRADE GLIOMAS; C-11 METHIONINE; BRAIN-TUMORS; BREAST-CANCER;
Keywords:
radiolabeled amino acids; C-11-methionine; C-11-tyrosine; I-123-iodo-alpha-methyltyrosine; tumor imaging;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
120
Recensione:
Indirizzi per estratti:
Indirizzo: Jager, PL Univ Groningen Hosp, Dept Nucl Med, PET Ctr, POB 30001, NL-9700 RB Groningen, Netherlands Univ Groningen Hosp POB 30001 Groningen Netherlands NL-9700 RB
Citazione:
P.L. Jager et al., "Radiolabeled amino acids: Basic aspects and clinical applications in oncology", J NUCL MED, 42(3), 2001, pp. 432-445

Abstract

As the applications of metabolic imaging are expanding, radiolabeled aminoacids may gain increased clinical interest, This review first describes the basic aspects of amino acid metabolism, then continues with basic aspectsof radiolabeled amino acids, and finally describes clinical applications, with an emphasis on diagnostic value. A special focus is on C-11-methionine, C-11-tyrosine, and I-123-iodomethyltyrosine, because these have been mostused clinically, although their common affinity for the L-transport systems may limit generalization to other classes of amino acids. The theoretic and preclinical background of amino acid imaging is sound and supports clinical applications. The fact that amino acid imaging is less influenced by inflammation may be advantageous in comparison with F-18-FDG PET imaging, although tumor specificity is not absolute. In brain tumor imaging, the use ofradiolabeled amino acids is established, the diagnostic accuracy of amino acid imaging seems adequate, and the diagnostic value seems advantageous. The general feasibility of amino acid imaging in other tumor types has sufficiently been shown, but more research is required in larger patient series and in well-defined clinical settings.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 02:36:58