Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Comparison of F-18-FDG, I-131-Na, and Tl-201 in diagnosis of recurrent or metastatic thyroid carcinoma
Autore:
Shiga, T; Tsukamoto, E; Nakada, K; Morita, K; Kato, T; Mabuchi, M; Yoshinaga, K; Katoh, C; Kuge, Y; Tamaki, N;
Indirizzi:
Hokkaido Univ, Sch Med, Dept Nucl Med, Kita Ku, Sapporo, Hokkaido 0608638,Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 poro, Hokkaido 0608638,Japan Hokkaido Univ, Sch Med, Dept Tracer Kinet, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 3, volume: 42, anno: 2001,
pagine: 414 - 419
SICI:
0161-5505(200103)42:3<414:COFIAT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOTAL-BODY SCINTIGRAPHY; FOLLOW-UP; CANCER; PET; SPECT; FLUORODEOXYGLUCOSE; FLUORINE-18-FDG; ONCOLOGY; THERAPY;
Keywords:
Tl-201 scintigraphy; I-131 scintigraphy; thyroid cancer; PET; F-18-FDG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Shiga, T Hokkaido Univ, Sch Med, Dept Nucl Med, Kita Ku, N 15th,W 7th, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ N 15th,W 7th Sapporo Hokkaido Japan 0608638 , Japan
Citazione:
T. Shiga et al., "Comparison of F-18-FDG, I-131-Na, and Tl-201 in diagnosis of recurrent or metastatic thyroid carcinoma", J NUCL MED, 42(3), 2001, pp. 414-419

Abstract

There are several reports about the usefulness of F-18-FDG PET in thyroid cancer. However, few studies have compared FDG PET with I-131 and Tl-201 scintigraphy. The aim of this study was to evaluate the clinical significanceof whole-body FDG PET in differentiated thyroid cancer and to compare the results with those obtained from I-131 and Tl-201 scintigraphy. Methods: Whole-body FDG PET was performed on 32 patients (10 men, 22 women; age range,30-77 y; mean age, 54 y) with differentiated thyroid cancer (5 cases of follicular cancer and 27 of papillary cancer) after total thyroidectomy. An overall clinical evaluation was performed, including cytology, thyroglobulinlevel, sonography, MRI, and CT, to allow a comparison with functional imaging results for each patient. Metastatic regions were divided into five areas: neck, lung, mediastinum, bone, and other. Multiple lesions in one area were defined as one lesion. The tumor-to-background ratio (TBR) was measured for the lesions that were positive for both Tl-201 uptake and FDG PET uptake. Results: The number of lesions totaled 47, Forty-one (87%) were detected by all scintigraphic methods. FDG uptake was concordant with I-131 uptake in only 18 lesions (38%). FDG uptake was concordant with Tl-201 uptake in44 lesions (94%), Only one lesion was negative for FDG uptake and positivefor Tl-201 uptake, and two lesions were positive for FDG uptake and negative for Tl-201 uptake. A significant correlation was seen between the TBR ofTl-201 and that of FDG (r = 0.69; P < 0.05). Conclusion: These data indicate that for detecting metastatic lesions, FDG PET and I-131 scintigraphy may provide complementary information, whereas FDG PET may provide results similar to those of Tl-201 scintigraphy. Thus, the combination of I-131 scintigraphy and FDG PET (or Tl-201 scintigraphy) is the method of choice for detecting metastatic thyroid cancer after total thyroidectomy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 18:27:01