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Titolo:
Ginsenoside Rb1 and Rg1 improve spatial learning and increase hippocampal synaptophysin level in mice
Autore:
Mook-Jung, I; Hong, HS; Boo, JH; Lee, KH; Yun, SH; Cheong, MY; Joo, I; Huh, K; Jung, MW;
Indirizzi:
Ajou Univ, Sch Med, Inst Med Sci, Neurosci Lab, Suwon 442721, South Korea Ajou Univ Suwon South Korea 442721 urosci Lab, Suwon 442721, South Korea Ajou Univ, Sch Med, Brain Dis Res Ctr, Suwon 442721, South Korea Ajou Univ Suwon South Korea 442721 is Res Ctr, Suwon 442721, South Korea Ajou Univ, Sch Med, Dept Neurol, Suwon 442721, South Korea Ajou Univ Suwon South Korea 442721 ept Neurol, Suwon 442721, South Korea
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 6, volume: 63, anno: 2001,
pagine: 509 - 515
SICI:
0360-4012(20010315)63:6<509:GRARIS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; CORTICAL CHOLINERGIC INNERVATION; DORSAL-ROOT-GANGLIA; ALZHEIMERS-DISEASE; EXTRACT IMPROVES; WORKING-MEMORY; ORGAN-CULTURES; RATS; SCOPOLAMINE; NEURONS;
Keywords:
hippocampus; water maze; spatial memory; cognitive enhancer; ginseng; long-term potentiation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Jung, MW Ajou Univ, Sch Med, Inst Med Sci, Neurosci Lab, Suwon 442721, South Korea Ajou Univ Suwon South Korea 442721 b, Suwon 442721, South Korea
Citazione:
I. Mook-Jung et al., "Ginsenoside Rb1 and Rg1 improve spatial learning and increase hippocampal synaptophysin level in mice", J NEUROSC R, 63(6), 2001, pp. 509-515

Abstract

We investigated the cognition enhancing effects of ginsenoside Rb1 and Rg1. Mice were trained in a Morris water maze following injection (i.p.) of Rb1 (1 mg/kg) or Rg1 (1 mg/kg) for 4 days. Both Rb1- and Rg1-injected mice showed enhanced spatial learning compared to control animals. The hippocampus, but not the frontal cortex, of treated mice contained higher density of asynaptic marker protein, synaptophysin, compared to control mice. Electrophysiological recordings in hippocampal slices revealed that Rb1 or Rg1 injection did not change the magnitude of paired-pulse facilitation or long-term potentiation. Our results suggest that Rb1 and Rg1 enhance spatial learning ability by increasing hippocampal synaptic density without changing plasticity of individual synapses. J. Neurosci. Res. 63:509-515, 2001. (C) 2001Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:20:26