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Titolo:
Activation of 5-HT1A but not 5-HT1B receptors attenuates an increase in extracellular dopamine derived from exogenously administered L-DOPA in the striatum with nigrostriatal denervation
Autore:
Kannari, K; Yamato, H; Shen, H; Tomiyama, M; Suda, T; Matsunaga, M;
Indirizzi:
Hirosaki Univ, Sch Med, Dept Med 3, Hirosaki, Aomori 0368216, Japan Hirosaki Univ Hirosaki Aomori Japan 0368216 rosaki, Aomori 0368216, Japan Hirosaki Univ, Sch Med, Dept Neurol, Hirosaki, Aomori 0368216, Japan Hirosaki Univ Hirosaki Aomori Japan 0368216 rosaki, Aomori 0368216, Japan
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 5, volume: 76, anno: 2001,
pagine: 1346 - 1353
SICI:
0022-3042(200103)76:5<1346:AO5BN5>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGONISTS ALNESPIRONE S-20499; LEVODOPA-INDUCED DYSKINESIAS; RAT STRIATUM; PHARMACOLOGICAL CHARACTERIZATION; 6-HYDROXYDOPAMINE-TREATED RATS; SELECTIVE AGONISTS; RELEASE INVIVO; CONSCIOUS RATS; BRAIN; 5-HYDROXYTRYPTAMINE;
Keywords:
5-HT1A receptor; 5-HT1B receptor; L-DOPA; dopamine; 6-OHDA-lesioned rat; microdialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Kannari, K Hirosaki Univ, Sch Med, Dept Med 3, 2 Zaifu Cho, Hirosaki, Aomori 0368216,Japan Hirosaki Univ 2 Zaifu Cho Hirosaki Aomori Japan 0368216 6,Japan
Citazione:
K. Kannari et al., "Activation of 5-HT1A but not 5-HT1B receptors attenuates an increase in extracellular dopamine derived from exogenously administered L-DOPA in the striatum with nigrostriatal denervation", J NEUROCHEM, 76(5), 2001, pp. 1346-1353

Abstract

In order to determine whether L-DOPA-derived extracellular dopamine (DA) in the striatum with dopaminergic denervation is affected by activation of serotonin autoreceptors (5-HT1A and 5-HT1B receptors), we applied in vivo brain microdialysis technique to 6-hydroxydopamine-lesioned rats and examinedthe effects of the selective 5-HT1A receptor agonist 8-hydroxy2-(di-n-propylamino)tetralin (8-OH-DPAT) and the selective S-HT1B receptor agonist CGS-12066 A on L-DOPA-derived extracellular DA levels. Single L-DOPA injection (50 mg/kg i.p.) caused a rapid increase and a following decrease of extracellular DA, with a peak value at 100 min after L-DOPA injection. Pretreatment with both 0.3 mg/kg and 1 mg/kg 8-OH-DPAT (i.p.) significantly attenuatedan increase in L-DOPA-derived extracellular DA and the times of peak DA levels were prolonged to 150 min and 225 min after L-DOPA injection, respectively. These 8-OH-DPAT-induced changes in L-DOPA-derived extracellular DA were antagonized by further pretreatment with WAY-100635, a selective 5-HT1A antagonist. In contrast, intrastriatal perfusion with the 5-HT1B agonist CGS-12066 A (10 nM and 100 nM) did not induce any changes in L-DOPA-derived extracellular DA. Thus, stimulation of 5-HT1A but not 5-HT1B receptors attenuated an increase in extracellular DA derived from exogenous L-DOPA. These results support the hypothesis that serotonergic neurons are primarily responsible for the storage and release of DA derived from exogenous L-DOPA in the absence of dopaminergic neurons.

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Documento generato il 04/04/20 alle ore 11:52:52