Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Encapsulation of retinoids in solid lipid nanoparticles (SLN (R))
Autore:
Jenning, V; Gohla, SH;
Indirizzi:
Free Univ Berlin, Dept Pharm Biopharmaceut & Biotechnol, D-12169 Berlin, Germany Free Univ Berlin Berlin Germany D-12169 technol, D-12169 Berlin, Germany
Titolo Testata:
JOURNAL OF MICROENCAPSULATION
fascicolo: 2, volume: 18, anno: 2001,
pagine: 149 - 158
SICI:
0265-2048(200103)18:2<149:EORISL>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Keywords:
solid lipid nanoparticles; retinoids; encapsulation efficacy; drug leakage; chemical stability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Gohla, SH Free Univ Berlin, Dept Pharm Biopharmaceut & Biotechnol, Kelchstr 31, D-12169 Berlin, Germany Free Univ Berlin Kelchstr 31 Berlin Germany D-12169 in, Germany
Citazione:
V. Jenning e S.H. Gohla, "Encapsulation of retinoids in solid lipid nanoparticles (SLN (R))", J MICROENC, 18(2), 2001, pp. 149-158

Abstract

SLN have been suggested for a broad range of applications, such as intravenous injection, peroral, or dermal administration. The incorporation of thedrug in the core of the SLN has to be ensured for these applications, but the inclusion of drugs in SLN is poorly understood. This study is a contribution to further describe the inclusion properties of colloidal lipids and to propose incorporation mechanisms. Besides the well known methods to investigate entrapment of actives in nanoparticles such as DSC or microscopy, the present study focussed on yet a different approach. Based on the different chemical stability of retinoids in water and in a lipid phase, a method to derive information on the distribution of the drug between SLN-lipid andthe water phase was established. Comparing different lipids, glyceryl behenate gave superior entrapment compared to tripalmitate, cetyl palmitate andsolid paraffin. Comparing three different drugs, entrapment increased withdecreasing polarity of the molecule (tretinoin < retinol < retinyl palmitate). The encapsulation efficacy was successfully enhanced by formulating SLN from mixtures of liquid and solid lipids. These particles were solid and provided better protection of the sensitive drugs than an emulsion. X-ray investigations revealed that good encapsulation correlated with a low degreeof crystallinity and lattice defects. With highly ordered crystals, as in the case of cetyl palmitate, drug expulsion from the carrier was more pronounced.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:56:42