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Titolo:
ApoE-containing high density lipoproteins and phospholipid transfer protein activity increase in patients with a systemic inflammatory response
Autore:
Barlage, S; Frohlich, D; Bottcher, A; Jauhiainen, M; Muller, HP; Noetzel, F; Rothe, G; Schutt, C; Linke, RP; Lackner, KJ; Ehnholm, C; Schmitz, G;
Indirizzi:
Univ Regensburg, Inst Clin Chem & Lab Med, D-93042 Regensburg, Germany Univ Regensburg Regensburg Germany D-93042 , D-93042 Regensburg, Germany Univ Regensburg, Dept Anesthesiol, D-93042 Regensburg, Germany Univ Regensburg Regensburg Germany D-93042 , D-93042 Regensburg, Germany Natl Publ Hlth Inst, Dept Biochem, FIN-00300 Helsinki, Finland Natl Publ Hlth Inst Helsinki Finland FIN-00300 N-00300 Helsinki, Finland Univ Greifswald, Inst Immunol & Transfus Med, D-17487 Greifswald, Germany Univ Greifswald Greifswald Germany D-17487 , D-17487 Greifswald, Germany Max Planck Inst Biochem, D-82152 Martinsried, Germany Max Planck Inst Biochem Martinsried Germany D-82152 Martinsried, Germany
Titolo Testata:
JOURNAL OF LIPID RESEARCH
fascicolo: 2, volume: 42, anno: 2001,
pagine: 281 - 290
SICI:
0022-2275(200102)42:2<281:AHDLAP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-A-I; LECITHIN-CHOLESTEROL ACYLTRANSFERASE; LIPOPOLYSACCHARIDE-BINDING PROTEIN; ESTER TRANSFER PROTEIN; HUMAN PLASMA; BLOOD-PLASMA; ISOTACHOPHORESIS; SPHINGOMYELIN; ENDOTOXEMIA; ANTIBODIES;
Keywords:
cholesteryl ester transfer protein; lipopolysaccharide-binding protein; inflammation; sepsis; isotachophoresis; apolipoprotein E;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Schmitz, G Univ Regensburg, Inst Clin Chem & Lab Med, Franz Josef Str Allee 11, D-93042 Regensburg, Germany Univ Regensburg Franz Josef Str Allee 11 Regensburg Germany D-93042
Citazione:
S. Barlage et al., "ApoE-containing high density lipoproteins and phospholipid transfer protein activity increase in patients with a systemic inflammatory response", J LIPID RES, 42(2), 2001, pp. 281-290

Abstract

High density lipoproteins (HDL) mediate reverse cholesterol transport as well as the clearance of oxidation products or inflammatory mediators, thereby contributing to tissue integrity. The decrease in HDL in inflammation has been attributed to decreased lecithin:cholesterol acyltransferase activity, whereas the role of phospholipid transfer protein (PLTP) and cholesterylester transfer protein has not been analyzed in detail. We have studied the activities of HDL-modifying proteins and the heterogeneity of HDL in healthy control subjects and three groups of postsurgery patients: no bacterialinfection (group I), bacterial focus and systemic inflammatory response (group 2), and severe sepsis (group 3), For all patients, a decrease in totalHDL could be demonstrated, with a loss of mainly large, apolipoprotein A-I(apoA-I) HDL particles, an almost total loss of apoC-I, and an increase inapoE HDL (200-500 kDa), which did not contain significant amounts of apoA-I, apoA-II, or apoC-I, PLTP activity was increased in patients of groups 2 and 3, paralleled by a redistribution of PLTP into a population of small (120- to 200-kDa) particles, probably representing PLTP homodimers or lipid-complexed PLTP. In summary, the increase in apoE HDL and PLTP activity may improve the delivery of energy substrates and phospholipids to tissues that must maintain cellular membrane homeostasis under conditions of inflammatory stress.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:11:43