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Titolo:
ApoA-II expression in CETP transgenic mice increases VLDL production and impairs VLDL clearance
Autore:
Escola-Gil, JC; Julve, J; Marzal-Casacuberta, A; Ordonez-Llanos, J; Gonzalez-Sastre, F; Blanco-Vaca, F;
Indirizzi:
Hosp Santa Creu & Sant Pau, Serv Bioquim, Barcelona 08025, Spain Hosp Santa Creu & Sant Pau Barcelona Spain 08025 Barcelona 08025, Spain Hosp Santa Creu & Sant Pau, Inst Recerca, Barcelona 08025, Spain Hosp Santa Creu & Sant Pau Barcelona Spain 08025 Barcelona 08025, Spain Univ Autonoma Barcelona, Dept Bioquim & Biol Mol, Barcelona 08025, Spain Univ Autonoma Barcelona Barcelona Spain 08025 ol, Barcelona 08025, Spain
Titolo Testata:
JOURNAL OF LIPID RESEARCH
fascicolo: 2, volume: 42, anno: 2001,
pagine: 241 - 248
SICI:
0022-2275(200102)42:2<241:AEICTM>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-A-II; ESTER TRANSFER PROTEIN; FAMILIAL COMBINED HYPERLIPIDEMIA; CHOLESTEROL ACYLTRANSFERASE DEFICIENCY; DENSITY-LIPOPROTEIN CHOLESTEROL; INCREASED ATHEROSCLEROSIS; FUNCTIONAL LECITHIN; UP-REGULATION; MOUSE MODELS; IN-VITRO;
Keywords:
atherosclerosis; cholesteryl ester transfer protein; high density lipoprotein; hypertrygliceridemia; very low density lipoprotein; familial combined hyperlipidemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Blanco-Vaca, F Hosp Santa Creu & Sant Pau, Serv Bioquim, C Antoni M Claret167, Barcelona08025, Spain Hosp Santa Creu & Sant Pau C Antoni M Claret 167 Barcelona Spain 08025
Citazione:
J.C. Escola-Gil et al., "ApoA-II expression in CETP transgenic mice increases VLDL production and impairs VLDL clearance", J LIPID RES, 42(2), 2001, pp. 241-248

Abstract

Apolipoprotein (apo)A-II is a major high density lipoprotein (HDL) protein; however, its role in lipoprotein metabolism is largely unknown. Transgenic (Tg) mice that overexpress human apoA-II present functional lecithin: cholesterol acyltransferase deficiency, HDL deficiency, hypertriglyceridemia and, when fed an atherogenic diet, increased non-HDL cholesterol and increased susceptibility to atherosclerosis. In contrast to humans, mice do riot present cholesteryl ester transfer protein (CETP) activity in plasma. To study the in vivo interaction of these two proteins, we crossbred human apoA-II and CETP-Tg mice. CETP x apoA-II-Tg mice fed an atherogenic diet, compared with CETP-Tg mice presented a 2-fold decrease in HDL cholesterol and a quantitatively similar increase in total plasma cholesterol and percentage offree cholesterol, non-HDL cholesterol, and free fatty acids, together witha remarkable 112-fold increase in plasma triglycerides, Plasma triglycerides in CETP x apoA-II-Tg mice were mainly associated with very low density lipoproteins (VLDL), which were also enriched in protein content, and resulted from a combination of higher production rate compared with both of theirprogenitors and non-Tg control mice, and decreased catabolism compared only with CETP-Tg mice. These results show CETP x apoA-II-Tg mice to be a goodmodel with which to study mechanisms leading to VLDL overproduction and suggest that CETP and, in particular apoA-II, may play a role in the regulation of VLDL metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 02:44:33